Synthesis and PI3 Kinase Inhibition Activity of Some Novel Trisubstituted Morpholinopyrimidines

A number of new substituted morpholinopyrimidines were prepared utilizing sequential nucleophilic aromatic substitution and cross-coupling reactions. One of the disubstituted pyrimidines was converted into two trisubstituted compounds which were screened as PI3K inhibitors relative to the well-chara...

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Detalles Bibliográficos
Autores principales: Wright, Emily W., Nelson, Ronald A., Karpova, Yelena, Kulik, George, Welker, Mark E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100461/
https://www.ncbi.nlm.nih.gov/pubmed/29996482
http://dx.doi.org/10.3390/molecules23071675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100461/
https://www.ncbi.nlm.nih.gov/pubmed/29996482
http://dx.doi.org/10.3390/molecules23071675

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