First Metal-Free Synthesis of Tetracyclic Pyrido and Pyrazino Thienopyrimidinone Molecules

We report herein a new metal free synthetic pathway to generate tetracyclic compounds from 3-aminothieno[3,2-b]pyridine-2-carboxylate. To enlarge the molecular diversity, we studied the Suzuki coupling of 9-chloro-6H-pyrido[1,2-a]pyrido[2′,3′:4,5]thieno[3,2-d]pyrimidin-6-one and several boronic acid...

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Autores principales: Aounzou, Mohammed, Campos, Joana F., Loubidi, Mohammed, Berteina-Raboin, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100531/
https://www.ncbi.nlm.nih.gov/pubmed/29751677
http://dx.doi.org/10.3390/molecules23051159
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author Aounzou, Mohammed
Campos, Joana F.
Loubidi, Mohammed
Berteina-Raboin, Sabine
author_facet Aounzou, Mohammed
Campos, Joana F.
Loubidi, Mohammed
Berteina-Raboin, Sabine
author_sort Aounzou, Mohammed
collection PubMed
description We report herein a new metal free synthetic pathway to generate tetracyclic compounds from 3-aminothieno[3,2-b]pyridine-2-carboxylate. To enlarge the molecular diversity, we studied the Suzuki coupling of 9-chloro-6H-pyrido[1,2-a]pyrido[2′,3′:4,5]thieno[3,2-d]pyrimidin-6-one and several boronic acids were easily introduced.
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spelling pubmed-61005312018-11-13 First Metal-Free Synthesis of Tetracyclic Pyrido and Pyrazino Thienopyrimidinone Molecules Aounzou, Mohammed Campos, Joana F. Loubidi, Mohammed Berteina-Raboin, Sabine Molecules Article We report herein a new metal free synthetic pathway to generate tetracyclic compounds from 3-aminothieno[3,2-b]pyridine-2-carboxylate. To enlarge the molecular diversity, we studied the Suzuki coupling of 9-chloro-6H-pyrido[1,2-a]pyrido[2′,3′:4,5]thieno[3,2-d]pyrimidin-6-one and several boronic acids were easily introduced. MDPI 2018-05-11 /pmc/articles/PMC6100531/ /pubmed/29751677 http://dx.doi.org/10.3390/molecules23051159 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aounzou, Mohammed
Campos, Joana F.
Loubidi, Mohammed
Berteina-Raboin, Sabine
First Metal-Free Synthesis of Tetracyclic Pyrido and Pyrazino Thienopyrimidinone Molecules
title First Metal-Free Synthesis of Tetracyclic Pyrido and Pyrazino Thienopyrimidinone Molecules
title_full First Metal-Free Synthesis of Tetracyclic Pyrido and Pyrazino Thienopyrimidinone Molecules
title_fullStr First Metal-Free Synthesis of Tetracyclic Pyrido and Pyrazino Thienopyrimidinone Molecules
title_full_unstemmed First Metal-Free Synthesis of Tetracyclic Pyrido and Pyrazino Thienopyrimidinone Molecules
title_short First Metal-Free Synthesis of Tetracyclic Pyrido and Pyrazino Thienopyrimidinone Molecules
title_sort first metal-free synthesis of tetracyclic pyrido and pyrazino thienopyrimidinone molecules
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100531/
https://www.ncbi.nlm.nih.gov/pubmed/29751677
http://dx.doi.org/10.3390/molecules23051159
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