Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon

Nerve agents and oxon forms of organophosphorus pesticides act as strong irreversible inhibitors of two cholinesterases in the human body: acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BChE; EC 3.1.1.8), and are therefore highly toxic compounds. For the recovery of inhibited ACh...

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Detalles Bibliográficos
Autores principales: Kuca, Kamil, Jun, Daniel, Junova, Lucie, Musilek, Kamil, Hrabinova, Martina, da Silva, Jorge Alberto Valle, Ramalho, Teodorico Castro, Valko, Marian, Wu, Qinghua, Nepovimova, Eugenie, França, Tanos Celmar Costa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100540/
https://www.ncbi.nlm.nih.gov/pubmed/29735900
http://dx.doi.org/10.3390/molecules23051103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100540/
https://www.ncbi.nlm.nih.gov/pubmed/29735900
http://dx.doi.org/10.3390/molecules23051103

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