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Synthesis and PI3 Kinase Inhibition Activity of a Wortmannin-Leucine Derivative

Wortmannin is a potent covalent inhibitor of PI3K that shows substantial in vivo toxicity and thus is unsuitable for systemic therapeutic applications. One possible approach to minimize systemic toxicity is to generate a latent wortmannin pro-drug that will be selectively activated in target tissues...

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Detalles Bibliográficos
Autores principales:	Cantrell, William, Huang, Yue, Menchaca, Antonio A., Kulik, George, Welker, Mark E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100554/ https://www.ncbi.nlm.nih.gov/pubmed/30036994 http://dx.doi.org/10.3390/molecules23071791

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