Cargando…
A Novel AgNPs/Sericin/Agar Film with Enhanced Mechanical Property and Antibacterial Capability
Silk sericin is a protein from a silkworm’s cocoon. It has good biocompatibility, hydrophilicity, bioactivity, and biodegradability. However, sericin could not be used in biomedical materials directly because of its frangible characteristic. To develop multifunctional sericin-based materials for bio...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100604/ https://www.ncbi.nlm.nih.gov/pubmed/30041405 http://dx.doi.org/10.3390/molecules23071821 |
_version_ | 1783348913507401728 |
---|---|
author | Wang, Yejing Cai, Rui Tao, Gang Wang, Peng Zuo, Hua Zhao, Ping Umar, Ahmad He, Huawei |
author_facet | Wang, Yejing Cai, Rui Tao, Gang Wang, Peng Zuo, Hua Zhao, Ping Umar, Ahmad He, Huawei |
author_sort | Wang, Yejing |
collection | PubMed |
description | Silk sericin is a protein from a silkworm’s cocoon. It has good biocompatibility, hydrophilicity, bioactivity, and biodegradability. However, sericin could not be used in biomedical materials directly because of its frangible characteristic. To develop multifunctional sericin-based materials for biomedical purposes, we prepared a sericin/agar (SS/agar) composite film through the blending of sericin and agar and repetitive freeze-thawing. Then, we synthesized silver nanoparticles (AgNPs) in situ on the surface of the composite film to endow it with antibacterial activity. Water contact angle, swelling and losing ratio, and mechanical properties analysis indicated that the composite film had excellent mechanical property, hydrophilicity, hygroscopicity, and stability. Scanning electron microscopy and X-ray photoelectron spectroscopy analysis confirmed the successful modification of AgNPs on the composite film. X-ray powder diffraction showed the face-centered cubic structures of the AgNPs. This AgNPs modified composite film exhibited an excellent antibacterial capability against Escherichia coli and Staphylococcus aureus. Our study develops a novel AgNPs/sericin/agar composite film with enhanced mechanical performance and an antimicrobial property for potential biomedical applications. |
format | Online Article Text |
id | pubmed-6100604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61006042018-11-13 A Novel AgNPs/Sericin/Agar Film with Enhanced Mechanical Property and Antibacterial Capability Wang, Yejing Cai, Rui Tao, Gang Wang, Peng Zuo, Hua Zhao, Ping Umar, Ahmad He, Huawei Molecules Article Silk sericin is a protein from a silkworm’s cocoon. It has good biocompatibility, hydrophilicity, bioactivity, and biodegradability. However, sericin could not be used in biomedical materials directly because of its frangible characteristic. To develop multifunctional sericin-based materials for biomedical purposes, we prepared a sericin/agar (SS/agar) composite film through the blending of sericin and agar and repetitive freeze-thawing. Then, we synthesized silver nanoparticles (AgNPs) in situ on the surface of the composite film to endow it with antibacterial activity. Water contact angle, swelling and losing ratio, and mechanical properties analysis indicated that the composite film had excellent mechanical property, hydrophilicity, hygroscopicity, and stability. Scanning electron microscopy and X-ray photoelectron spectroscopy analysis confirmed the successful modification of AgNPs on the composite film. X-ray powder diffraction showed the face-centered cubic structures of the AgNPs. This AgNPs modified composite film exhibited an excellent antibacterial capability against Escherichia coli and Staphylococcus aureus. Our study develops a novel AgNPs/sericin/agar composite film with enhanced mechanical performance and an antimicrobial property for potential biomedical applications. MDPI 2018-07-23 /pmc/articles/PMC6100604/ /pubmed/30041405 http://dx.doi.org/10.3390/molecules23071821 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wang, Yejing Cai, Rui Tao, Gang Wang, Peng Zuo, Hua Zhao, Ping Umar, Ahmad He, Huawei A Novel AgNPs/Sericin/Agar Film with Enhanced Mechanical Property and Antibacterial Capability |
title | A Novel AgNPs/Sericin/Agar Film with Enhanced Mechanical Property and Antibacterial Capability |
title_full | A Novel AgNPs/Sericin/Agar Film with Enhanced Mechanical Property and Antibacterial Capability |
title_fullStr | A Novel AgNPs/Sericin/Agar Film with Enhanced Mechanical Property and Antibacterial Capability |
title_full_unstemmed | A Novel AgNPs/Sericin/Agar Film with Enhanced Mechanical Property and Antibacterial Capability |
title_short | A Novel AgNPs/Sericin/Agar Film with Enhanced Mechanical Property and Antibacterial Capability |
title_sort | novel agnps/sericin/agar film with enhanced mechanical property and antibacterial capability |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100604/ https://www.ncbi.nlm.nih.gov/pubmed/30041405 http://dx.doi.org/10.3390/molecules23071821 |
work_keys_str_mv | AT wangyejing anovelagnpssericinagarfilmwithenhancedmechanicalpropertyandantibacterialcapability AT cairui anovelagnpssericinagarfilmwithenhancedmechanicalpropertyandantibacterialcapability AT taogang anovelagnpssericinagarfilmwithenhancedmechanicalpropertyandantibacterialcapability AT wangpeng anovelagnpssericinagarfilmwithenhancedmechanicalpropertyandantibacterialcapability AT zuohua anovelagnpssericinagarfilmwithenhancedmechanicalpropertyandantibacterialcapability AT zhaoping anovelagnpssericinagarfilmwithenhancedmechanicalpropertyandantibacterialcapability AT umarahmad anovelagnpssericinagarfilmwithenhancedmechanicalpropertyandantibacterialcapability AT hehuawei anovelagnpssericinagarfilmwithenhancedmechanicalpropertyandantibacterialcapability AT wangyejing novelagnpssericinagarfilmwithenhancedmechanicalpropertyandantibacterialcapability AT cairui novelagnpssericinagarfilmwithenhancedmechanicalpropertyandantibacterialcapability AT taogang novelagnpssericinagarfilmwithenhancedmechanicalpropertyandantibacterialcapability AT wangpeng novelagnpssericinagarfilmwithenhancedmechanicalpropertyandantibacterialcapability AT zuohua novelagnpssericinagarfilmwithenhancedmechanicalpropertyandantibacterialcapability AT zhaoping novelagnpssericinagarfilmwithenhancedmechanicalpropertyandantibacterialcapability AT umarahmad novelagnpssericinagarfilmwithenhancedmechanicalpropertyandantibacterialcapability AT hehuawei novelagnpssericinagarfilmwithenhancedmechanicalpropertyandantibacterialcapability |