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A Novel AgNPs/Sericin/Agar Film with Enhanced Mechanical Property and Antibacterial Capability

Silk sericin is a protein from a silkworm’s cocoon. It has good biocompatibility, hydrophilicity, bioactivity, and biodegradability. However, sericin could not be used in biomedical materials directly because of its frangible characteristic. To develop multifunctional sericin-based materials for bio...

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Detalles Bibliográficos
Autores principales: Wang, Yejing, Cai, Rui, Tao, Gang, Wang, Peng, Zuo, Hua, Zhao, Ping, Umar, Ahmad, He, Huawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100604/
https://www.ncbi.nlm.nih.gov/pubmed/30041405
http://dx.doi.org/10.3390/molecules23071821
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author Wang, Yejing
Cai, Rui
Tao, Gang
Wang, Peng
Zuo, Hua
Zhao, Ping
Umar, Ahmad
He, Huawei
author_facet Wang, Yejing
Cai, Rui
Tao, Gang
Wang, Peng
Zuo, Hua
Zhao, Ping
Umar, Ahmad
He, Huawei
author_sort Wang, Yejing
collection PubMed
description Silk sericin is a protein from a silkworm’s cocoon. It has good biocompatibility, hydrophilicity, bioactivity, and biodegradability. However, sericin could not be used in biomedical materials directly because of its frangible characteristic. To develop multifunctional sericin-based materials for biomedical purposes, we prepared a sericin/agar (SS/agar) composite film through the blending of sericin and agar and repetitive freeze-thawing. Then, we synthesized silver nanoparticles (AgNPs) in situ on the surface of the composite film to endow it with antibacterial activity. Water contact angle, swelling and losing ratio, and mechanical properties analysis indicated that the composite film had excellent mechanical property, hydrophilicity, hygroscopicity, and stability. Scanning electron microscopy and X-ray photoelectron spectroscopy analysis confirmed the successful modification of AgNPs on the composite film. X-ray powder diffraction showed the face-centered cubic structures of the AgNPs. This AgNPs modified composite film exhibited an excellent antibacterial capability against Escherichia coli and Staphylococcus aureus. Our study develops a novel AgNPs/sericin/agar composite film with enhanced mechanical performance and an antimicrobial property for potential biomedical applications.
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spelling pubmed-61006042018-11-13 A Novel AgNPs/Sericin/Agar Film with Enhanced Mechanical Property and Antibacterial Capability Wang, Yejing Cai, Rui Tao, Gang Wang, Peng Zuo, Hua Zhao, Ping Umar, Ahmad He, Huawei Molecules Article Silk sericin is a protein from a silkworm’s cocoon. It has good biocompatibility, hydrophilicity, bioactivity, and biodegradability. However, sericin could not be used in biomedical materials directly because of its frangible characteristic. To develop multifunctional sericin-based materials for biomedical purposes, we prepared a sericin/agar (SS/agar) composite film through the blending of sericin and agar and repetitive freeze-thawing. Then, we synthesized silver nanoparticles (AgNPs) in situ on the surface of the composite film to endow it with antibacterial activity. Water contact angle, swelling and losing ratio, and mechanical properties analysis indicated that the composite film had excellent mechanical property, hydrophilicity, hygroscopicity, and stability. Scanning electron microscopy and X-ray photoelectron spectroscopy analysis confirmed the successful modification of AgNPs on the composite film. X-ray powder diffraction showed the face-centered cubic structures of the AgNPs. This AgNPs modified composite film exhibited an excellent antibacterial capability against Escherichia coli and Staphylococcus aureus. Our study develops a novel AgNPs/sericin/agar composite film with enhanced mechanical performance and an antimicrobial property for potential biomedical applications. MDPI 2018-07-23 /pmc/articles/PMC6100604/ /pubmed/30041405 http://dx.doi.org/10.3390/molecules23071821 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Yejing
Cai, Rui
Tao, Gang
Wang, Peng
Zuo, Hua
Zhao, Ping
Umar, Ahmad
He, Huawei
A Novel AgNPs/Sericin/Agar Film with Enhanced Mechanical Property and Antibacterial Capability
title A Novel AgNPs/Sericin/Agar Film with Enhanced Mechanical Property and Antibacterial Capability
title_full A Novel AgNPs/Sericin/Agar Film with Enhanced Mechanical Property and Antibacterial Capability
title_fullStr A Novel AgNPs/Sericin/Agar Film with Enhanced Mechanical Property and Antibacterial Capability
title_full_unstemmed A Novel AgNPs/Sericin/Agar Film with Enhanced Mechanical Property and Antibacterial Capability
title_short A Novel AgNPs/Sericin/Agar Film with Enhanced Mechanical Property and Antibacterial Capability
title_sort novel agnps/sericin/agar film with enhanced mechanical property and antibacterial capability
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100604/
https://www.ncbi.nlm.nih.gov/pubmed/30041405
http://dx.doi.org/10.3390/molecules23071821
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