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Anti-Inflammatory Effects of Fargesin on Chemically Induced Inflammatory Bowel Disease in Mice
Fargesin is a bioactive lignan from Flos Magnoliae, an herb widely used in the treatment of allergic rhinitis, sinusitis, and headache in Asia. We sought to investigate whether fargesin ameliorates experimental inflammatory bowel disease (IBD) in mice. Oral administration of fargesin significantly a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100621/ https://www.ncbi.nlm.nih.gov/pubmed/29880739 http://dx.doi.org/10.3390/molecules23061380 |
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author | Yue, Bei Ren, Yi-Jing Zhang, Jing-Jing Luo, Xiao-Ping Yu, Zhi-Lun Ren, Gai-Yan Sun, A-Ning Deng, Chao Wang, Zheng-Tao Dou, Wei |
author_facet | Yue, Bei Ren, Yi-Jing Zhang, Jing-Jing Luo, Xiao-Ping Yu, Zhi-Lun Ren, Gai-Yan Sun, A-Ning Deng, Chao Wang, Zheng-Tao Dou, Wei |
author_sort | Yue, Bei |
collection | PubMed |
description | Fargesin is a bioactive lignan from Flos Magnoliae, an herb widely used in the treatment of allergic rhinitis, sinusitis, and headache in Asia. We sought to investigate whether fargesin ameliorates experimental inflammatory bowel disease (IBD) in mice. Oral administration of fargesin significantly attenuated the symptoms of dextran sulfate sodium (DSS)-induced colitis in mice by decreasing the inflammatory infiltration and myeloperoxidase (MPO) activity, reducing tumor necrosis factor (TNF)-α secretion, and inhibiting nitric oxide (NO) production in colitis mice. The degradation of inhibitory κBα (IκBα), phosphorylation of p65, and mRNA expression of nuclear factor κB (NF-κB) target genes were inhibited by fargesin treatment in the colon of the colitis mice. In vitro, fargesin blocked the nuclear translocation of p-p65, downregulated the protein levels of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), and dose-dependently inhibited the activity of NF-κB-luciferase in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Taken together, for the first time, the current study demonstrated the anti-inflammatory effects of fargesin on chemically induced IBD might be associated with NF-κB signaling suppression. The findings may contribute to the development of therapies for human IBD by using fargesin or its derivatives. |
format | Online Article Text |
id | pubmed-6100621 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61006212018-11-13 Anti-Inflammatory Effects of Fargesin on Chemically Induced Inflammatory Bowel Disease in Mice Yue, Bei Ren, Yi-Jing Zhang, Jing-Jing Luo, Xiao-Ping Yu, Zhi-Lun Ren, Gai-Yan Sun, A-Ning Deng, Chao Wang, Zheng-Tao Dou, Wei Molecules Article Fargesin is a bioactive lignan from Flos Magnoliae, an herb widely used in the treatment of allergic rhinitis, sinusitis, and headache in Asia. We sought to investigate whether fargesin ameliorates experimental inflammatory bowel disease (IBD) in mice. Oral administration of fargesin significantly attenuated the symptoms of dextran sulfate sodium (DSS)-induced colitis in mice by decreasing the inflammatory infiltration and myeloperoxidase (MPO) activity, reducing tumor necrosis factor (TNF)-α secretion, and inhibiting nitric oxide (NO) production in colitis mice. The degradation of inhibitory κBα (IκBα), phosphorylation of p65, and mRNA expression of nuclear factor κB (NF-κB) target genes were inhibited by fargesin treatment in the colon of the colitis mice. In vitro, fargesin blocked the nuclear translocation of p-p65, downregulated the protein levels of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), and dose-dependently inhibited the activity of NF-κB-luciferase in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Taken together, for the first time, the current study demonstrated the anti-inflammatory effects of fargesin on chemically induced IBD might be associated with NF-κB signaling suppression. The findings may contribute to the development of therapies for human IBD by using fargesin or its derivatives. MDPI 2018-06-07 /pmc/articles/PMC6100621/ /pubmed/29880739 http://dx.doi.org/10.3390/molecules23061380 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yue, Bei Ren, Yi-Jing Zhang, Jing-Jing Luo, Xiao-Ping Yu, Zhi-Lun Ren, Gai-Yan Sun, A-Ning Deng, Chao Wang, Zheng-Tao Dou, Wei Anti-Inflammatory Effects of Fargesin on Chemically Induced Inflammatory Bowel Disease in Mice |
title | Anti-Inflammatory Effects of Fargesin on Chemically Induced Inflammatory Bowel Disease in Mice |
title_full | Anti-Inflammatory Effects of Fargesin on Chemically Induced Inflammatory Bowel Disease in Mice |
title_fullStr | Anti-Inflammatory Effects of Fargesin on Chemically Induced Inflammatory Bowel Disease in Mice |
title_full_unstemmed | Anti-Inflammatory Effects of Fargesin on Chemically Induced Inflammatory Bowel Disease in Mice |
title_short | Anti-Inflammatory Effects of Fargesin on Chemically Induced Inflammatory Bowel Disease in Mice |
title_sort | anti-inflammatory effects of fargesin on chemically induced inflammatory bowel disease in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100621/ https://www.ncbi.nlm.nih.gov/pubmed/29880739 http://dx.doi.org/10.3390/molecules23061380 |
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