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Osteogenesis imperfecta: potential therapeutic approaches

Osteogenesis imperfecta (OI) is a genetic disorder that is usually caused by disturbed production of collagen type I. Depending on its severity in the patient, this disorder may create difficulties and challenges for the dental practitioner. The goal of this article is to provide guidelines based on...

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Autores principales: Rousseau, Maxime, Retrouvey, Jean-Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100848/
https://www.ncbi.nlm.nih.gov/pubmed/30128210
http://dx.doi.org/10.7717/peerj.5464
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author Rousseau, Maxime
Retrouvey, Jean-Marc
author_facet Rousseau, Maxime
Retrouvey, Jean-Marc
author_sort Rousseau, Maxime
collection PubMed
description Osteogenesis imperfecta (OI) is a genetic disorder that is usually caused by disturbed production of collagen type I. Depending on its severity in the patient, this disorder may create difficulties and challenges for the dental practitioner. The goal of this article is to provide guidelines based on scientific evidence found in the current literature for practitioners who are or will be involved in the care of these patients. A prudent approach is recommended, as individuals affected by OI present with specific dentoalveolar problems that may prove very difficult to address. Recommended treatments for damaged/decayed teeth in the primary dentition are full-coverage restorations, including stainless steel crowns or zirconia crowns. Full-coverage restorations are also recommended in the permanent dentition. Intracoronal restorations should be avoided, as they promote structural tooth loss. Simple extractions can also be performed, but not immediately before or after intravenous bisphosphonate infusions. Clear aligners are a promising option for orthodontic treatment. In severe OI types, such as III or IV, orthognathic surgery is discouraged, despite the significant skeletal dysplasia present. Given the great variations in the severity of OI and the limited quantity of information available, the best treatment option relies heavily on the practitioner’s preliminary examination and judgment. A multidisciplinary team approach is encouraged and favored in more severe cases, in order to optimize diagnosis and treatment.
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spelling pubmed-61008482018-08-20 Osteogenesis imperfecta: potential therapeutic approaches Rousseau, Maxime Retrouvey, Jean-Marc PeerJ Genetics Osteogenesis imperfecta (OI) is a genetic disorder that is usually caused by disturbed production of collagen type I. Depending on its severity in the patient, this disorder may create difficulties and challenges for the dental practitioner. The goal of this article is to provide guidelines based on scientific evidence found in the current literature for practitioners who are or will be involved in the care of these patients. A prudent approach is recommended, as individuals affected by OI present with specific dentoalveolar problems that may prove very difficult to address. Recommended treatments for damaged/decayed teeth in the primary dentition are full-coverage restorations, including stainless steel crowns or zirconia crowns. Full-coverage restorations are also recommended in the permanent dentition. Intracoronal restorations should be avoided, as they promote structural tooth loss. Simple extractions can also be performed, but not immediately before or after intravenous bisphosphonate infusions. Clear aligners are a promising option for orthodontic treatment. In severe OI types, such as III or IV, orthognathic surgery is discouraged, despite the significant skeletal dysplasia present. Given the great variations in the severity of OI and the limited quantity of information available, the best treatment option relies heavily on the practitioner’s preliminary examination and judgment. A multidisciplinary team approach is encouraged and favored in more severe cases, in order to optimize diagnosis and treatment. PeerJ Inc. 2018-08-17 /pmc/articles/PMC6100848/ /pubmed/30128210 http://dx.doi.org/10.7717/peerj.5464 Text en © 2018 Rousseau et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Genetics
Rousseau, Maxime
Retrouvey, Jean-Marc
Osteogenesis imperfecta: potential therapeutic approaches
title Osteogenesis imperfecta: potential therapeutic approaches
title_full Osteogenesis imperfecta: potential therapeutic approaches
title_fullStr Osteogenesis imperfecta: potential therapeutic approaches
title_full_unstemmed Osteogenesis imperfecta: potential therapeutic approaches
title_short Osteogenesis imperfecta: potential therapeutic approaches
title_sort osteogenesis imperfecta: potential therapeutic approaches
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100848/
https://www.ncbi.nlm.nih.gov/pubmed/30128210
http://dx.doi.org/10.7717/peerj.5464
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