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A short-chain fatty acid, propionate, enhances the cytotoxic effect of cisplatin by modulating GPR41 signaling pathways in HepG2 cells

Short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate are generated by microbial fermentation of indigestible fiber by gut flora. SCFAs are ligands of two orphan G protein-coupled receptors, GPR41 and GPR43, that modulate cell proliferation and induce apoptosis. However, it is un...

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Detalles Bibliográficos
Autores principales:	Kobayashi, Mamiko, Mikami, Daisuke, Uwada, Junsuke, Yazawa, Takashi, Kamiyama, Kazuko, Kimura, Hideki, Taniguchi, Takanobu, Iwano, Masayuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101142/ https://www.ncbi.nlm.nih.gov/pubmed/30140374 http://dx.doi.org/10.18632/oncotarget.25809

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