The combination of epigenetic drugs SAHA and HCI-2509 synergistically inhibits EWS-FLI1 and tumor growth in Ewing sarcoma

PURPOSE: Epigenetic regulation is crucial in mammalian development and maintenance of tissue-cell specific functions. Perturbation of epigenetic balance may lead to alterations in gene expression, resulting in cellular transformation and malignancy. Previous studies in Ewing sarcoma (ES) have shown...

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Detalles Bibliográficos
Autores principales: García-Domínguez, Daniel Jose, Hontecillas-Prieto, Lourdes, Rodríguez-Núñez, Pablo, Pascual-Pasto, Guillem, Vila-Ubach, Monica, García-Mejías, Rosa, Robles, María José, Tirado, Oscar M., Mora, Jaume, Carcaboso, Angel M., de Álava, Enrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101143/
https://www.ncbi.nlm.nih.gov/pubmed/30140378
http://dx.doi.org/10.18632/oncotarget.25829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101143/
https://www.ncbi.nlm.nih.gov/pubmed/30140378
http://dx.doi.org/10.18632/oncotarget.25829

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