Ranolazine-induced Elevation of Creatinine Kinase in the Absence of Statin Usage

Ranolazine received Food and Drug Administration (FDA) approval in 2006 for the treatment of chronic angina. Ranolazine has previously been linked to the development of statin-induced myopathy, because it also inhibits CYP3A4, which increases serum statin levels. In the absence of concomitant statin...

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Autores principales: Dein, Eric, Manno, Rebecca, Syed, Abrahim, Douglas, Homeyra, Geetha, Duvuru, Timlin, Homa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2018
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101463/
https://www.ncbi.nlm.nih.gov/pubmed/30131925
http://dx.doi.org/10.7759/cureus.2832
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author Dein, Eric
Manno, Rebecca
Syed, Abrahim
Douglas, Homeyra
Geetha, Duvuru
Timlin, Homa
author_facet Dein, Eric
Manno, Rebecca
Syed, Abrahim
Douglas, Homeyra
Geetha, Duvuru
Timlin, Homa
author_sort Dein, Eric
collection PubMed
description Ranolazine received Food and Drug Administration (FDA) approval in 2006 for the treatment of chronic angina. Ranolazine has previously been linked to the development of statin-induced myopathy, because it also inhibits CYP3A4, which increases serum statin levels. In the absence of concomitant statin therapy, elevated creatinine kinase (CK) and myalgias on ranolazine monotherapy has never been reported.
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spelling pubmed-61014632018-08-21 Ranolazine-induced Elevation of Creatinine Kinase in the Absence of Statin Usage Dein, Eric Manno, Rebecca Syed, Abrahim Douglas, Homeyra Geetha, Duvuru Timlin, Homa Cureus Internal Medicine Ranolazine received Food and Drug Administration (FDA) approval in 2006 for the treatment of chronic angina. Ranolazine has previously been linked to the development of statin-induced myopathy, because it also inhibits CYP3A4, which increases serum statin levels. In the absence of concomitant statin therapy, elevated creatinine kinase (CK) and myalgias on ranolazine monotherapy has never been reported. Cureus 2018-06-18 /pmc/articles/PMC6101463/ /pubmed/30131925 http://dx.doi.org/10.7759/cureus.2832 Text en Copyright © 2018, Dein et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Dein, Eric
Manno, Rebecca
Syed, Abrahim
Douglas, Homeyra
Geetha, Duvuru
Timlin, Homa
Ranolazine-induced Elevation of Creatinine Kinase in the Absence of Statin Usage
title Ranolazine-induced Elevation of Creatinine Kinase in the Absence of Statin Usage
title_full Ranolazine-induced Elevation of Creatinine Kinase in the Absence of Statin Usage
title_fullStr Ranolazine-induced Elevation of Creatinine Kinase in the Absence of Statin Usage
title_full_unstemmed Ranolazine-induced Elevation of Creatinine Kinase in the Absence of Statin Usage
title_short Ranolazine-induced Elevation of Creatinine Kinase in the Absence of Statin Usage
title_sort ranolazine-induced elevation of creatinine kinase in the absence of statin usage
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101463/
https://www.ncbi.nlm.nih.gov/pubmed/30131925
http://dx.doi.org/10.7759/cureus.2832
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