Cargando…

SRSF9 selectively represses ADAR2-mediated editing of brain-specific sites in primates

Adenosine-to-inosine (A-to-I) RNA editing displays diverse spatial patterns across different tissues. However, the human genome encodes only two catalytically active editing enzymes (ADAR1 and ADAR2), suggesting that other regulatory factors help shape the editing landscape. Here, we show that the s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shanmugam, Raghuvaran, Zhang, Fan, Srinivasan, Harini, Charles Richard, John Lalith, Liu, Kaiwen I, Zhang, Xiujun, Woo, Cheok Wei A, Chua, Zi Hao M, Buschdorf, Jan Paul, Meaney, Michael J, Tan, Meng How
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101530/ https://www.ncbi.nlm.nih.gov/pubmed/29992293 http://dx.doi.org/10.1093/nar/gky615

Ejemplares similares

Tissue-selective restriction of RNA editing of Ca(V)1.3 by splicing factor SRSF9
por: Huang, Hua, et al.
Publicado: (2018)

Sequence-dependent recruitment of SRSF1 and SRSF7 to intronless lncRNA NKILA promotes nuclear export via the TREX/TAP pathway
por: Khan, Misbah, et al.
Publicado: (2021)

An internal deletion of ADAR rescued by MAVS deficiency leads to a minute phenotype
por: Bajad, Prajakta, et al.
Publicado: (2020)

Poison cassette exon splicing of SRSF6 regulates nuclear speckle dispersal and the response to hypoxia
por: de Oliveira Freitas Machado, Camila, et al.
Publicado: (2023)

ADAR2/miR-589-3p axis controls glioblastoma cell migration/invasion
por: Cesarini, Valeriana, et al.
Publicado: (2018)

Trypanosome RNA helicase KREH2 differentially controls non-canonical editing and putative repressive structure via a novel proposed ‘bifunctional’ gRNA in mRNA A6
por: Meehan, Joshua, et al.
Publicado: (2023)

Structure and dynamics of the quaternary hunchback mRNA translation repression complex
por: Macošek, Jakub, et al.
Publicado: (2021)

Argonaute binding within 3′-untranslated regions poorly predicts gene repression
por: Chu, Yongjun, et al.
Publicado: (2020)

DDX3 depletion represses translation of mRNAs with complex 5′ UTRs
por: Calviello, Lorenzo, et al.
Publicado: (2021)

Stabilization of Hfq-mediated translational repression by the co-repressor Crc in Pseudomonas aeruginosa
por: Malecka, Ewelina M, et al.
Publicado: (2021)

Direct role for the Drosophila GIGYF protein in 4EHP-mediated mRNA repression
por: Ruscica, Vincenzo, et al.
Publicado: (2019)

Intrinsic and regulated properties of minimally edited trypanosome mRNAs
por: Tylec, Brianna L, et al.
Publicado: (2019)

4EHP-independent repression of endogenous mRNAs by the RNA-binding protein GIGYF2
por: Amaya Ramirez, Cinthia C, et al.
Publicado: (2018)

RNA-binding protein DDX1 is responsible for fatty acid-mediated repression of insulin translation
por: Li, Zonghong, et al.
Publicado: (2018)

HuB and HuD repress telomerase activity by dissociating HuR from TERC
por: Cheng, Xiaolei, et al.
Publicado: (2021)

The RNA binding protein Quaking represses splicing of the Fibronectin EDA exon and downregulates the interferon response
por: Liao, Kuo-Chieh, et al.
Publicado: (2021)

Post-transcriptional repression of CFP-1 expands the regulatory repertoire of LIN-41/TRIM71
por: Kumari, Pooja, et al.
Publicado: (2023)

Gene fragmentation and RNA editing without borders: eccentric mitochondrial genomes of diplonemids
por: Kaur, Binnypreet, et al.
Publicado: (2020)

Reducing the inherent auto-inhibitory interaction within the pegRNA enhances prime editing efficiency
por: Ponnienselvan, Karthikeyan, et al.
Publicado: (2023)

Developmental regulation of edited CYb and COIII mitochondrial mRNAs is achieved by distinct mechanisms in Trypanosoma brucei
por: Smith Jr., Joseph T, et al.
Publicado: (2020)

RNA editing of microtubule-associated protein tau circular RNAs promotes their translation and tau tangle formation
por: Welden, Justin Ralph, et al.
Publicado: (2022)

Structural basis of tRNA(Pro) acceptor stem recognition by a bacterial trans-editing domain
por: Ma, Xiao, et al.
Publicado: (2023)

Structural characterization of maternally expressed gene 3 RNA reveals conserved motifs and potential sites of interaction with polycomb repressive complex 2
por: Sherpa, Chringma, et al.
Publicado: (2018)

Condensin I and condensin II proteins form a LINE-1 dependent super condensin complex and cooperate to repress LINE-1
por: Ward, Jacqueline R, et al.
Publicado: (2022)

Structure-based screening for functional non-coding RNAs in fission yeast identifies a factor repressing untimely initiation of sexual differentiation
por: Ono, Yu, et al.
Publicado: (2022)

Domain function and predicted structure of three heterodimeric endonuclease subunits of RNA editing catalytic complexes in Trypanosoma brucei
por: Carnes, Jason, et al.
Publicado: (2022)

Bidirectional regulation of adenosine-to-inosine (A-to-I) RNA editing by DEAH box helicase 9 (DHX9) in cancer
por: Hong, HuiQi, et al.
Publicado: (2018)

Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects
por: Keegan, Liam P., et al.
Publicado: (2011)

Zinc finger protein ZFP36L1 inhibits influenza A virus through translational repression by targeting HA, M and NS RNA transcripts
por: Lin, Ren-Jye, et al.
Publicado: (2020)

KREH1 RNA helicase activity promotes utilization of initiator gRNAs across multiple mRNAs in trypanosome RNA editing
por: Dubey, Ashutosh P, et al.
Publicado: (2023)

Dissecting the splicing mechanism of the Drosophila editing enzyme; dADAR
por: Marcucci, Roberto, et al.
Publicado: (2009)

Cell-line specific RNA editing patterns in Trypanosoma brucei suggest a unique mechanism to generate protein variation in a system intolerant to genetic mutations
por: Kirby, Laura E, et al.
Publicado: (2020)

Identification, functional characterization, assembly and structure of ToxIN type III toxin–antitoxin complex from E. coli
por: Manikandan, Parthasarathy, et al.
Publicado: (2022)

Editing of HIV-1 RNA by the double-stranded RNA deaminase ADAR1 stimulates viral infection
por: Doria, Margherita, et al.
Publicado: (2009)

A mechanism underlying position-specific regulation of alternative splicing
por: Hamid, Fursham M., et al.
Publicado: (2017)

A cautionary tale of sense-antisense gene pairs: independent regulation despite inverse correlation of expression
por: Goyal, Ashish, et al.
Publicado: (2017)

Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism
por: Scott, Daniel D., et al.
Publicado: (2017)

The RNA binding protein EWS is broadly involved in the regulation of pri-miRNA processing in mammalian cells
por: Ouyang, Huiwu, et al.
Publicado: (2017)

The MRPP1/MRPP2 complex is a tRNA-maturation platform in human mitochondria
por: Reinhard, Linda, et al.
Publicado: (2017)

Novel mechanisms of eIF2B action and regulation by eIF2α phosphorylation
por: Bogorad, Andrew M., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_q1ed3n1ks8e7u88n3hu1tpoiom