The landscape of the non-canonical RNA-binding site of Gemin5 unveils a feedback loop counteracting the negative effect on translation

Gemin5 is a predominantly cytoplasmic protein that downregulates translation, beyond controlling snRNPs assembly. The C-terminal region harbors a non-canonical RNA-binding site consisting of two domains, RBS1 and RBS2, which differ in RNA-binding capacity and the ability to modulate translation. Her...

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Detalles Bibliográficos
Autores principales: Francisco-Velilla, Rosario, Fernandez-Chamorro, Javier, Dotu, Ivan, Martinez-Salas, Encarnación
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101553/
https://www.ncbi.nlm.nih.gov/pubmed/29771365
http://dx.doi.org/10.1093/nar/gky361

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