Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine-rich head region

ATP is the native agonist for cell-surface ligand-gated P2X receptor (P2XR) cation channels. The seven mammalian subunits (P2X1–7) form homo- and heterotrimeric P2XRs having significant physiological and pathophysiological roles. Pyridoxalphosphate-6-azophenyl-2′,4′-disulfonic acid (PPADS) is an eff...

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Detalles Bibliográficos
Autores principales: Huo, Hong, Fryatt, Alistair G., Farmer, Louise K., Schmid, Ralf, Evans, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102130/
https://www.ncbi.nlm.nih.gov/pubmed/29997254
http://dx.doi.org/10.1074/jbc.RA118.003737

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102130/
https://www.ncbi.nlm.nih.gov/pubmed/29997254
http://dx.doi.org/10.1074/jbc.RA118.003737

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