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Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine-rich head region

ATP is the native agonist for cell-surface ligand-gated P2X receptor (P2XR) cation channels. The seven mammalian subunits (P2X1–7) form homo- and heterotrimeric P2XRs having significant physiological and pathophysiological roles. Pyridoxalphosphate-6-azophenyl-2′,4′-disulfonic acid (PPADS) is an eff...

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Detalles Bibliográficos
Autores principales:	Huo, Hong, Fryatt, Alistair G., Farmer, Louise K., Schmid, Ralf, Evans, Richard J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102130/ https://www.ncbi.nlm.nih.gov/pubmed/29997254 http://dx.doi.org/10.1074/jbc.RA118.003737

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