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Mechanical transduction of cytoplasmic-to-transmembrane-domain movements in a hyperpolarization-activated cyclic nucleotide–gated cation channel

Hyperpolarization-activated cyclic nucleotide–gated cation (HCN) channels play a critical role in the control of pacemaking in the heart and repetitive firing in neurons. In HCN channels, the intracellular cyclic nucleotide–binding domain (CNBD) is connected to the transmembrane portion of the chann...

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Detalles Bibliográficos
Autores principales:	Gross, Christine, Saponaro, Andrea, Santoro, Bina, Moroni, Anna, Thiel, Gerhard, Hamacher, Kay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102142/ https://www.ncbi.nlm.nih.gov/pubmed/29936413 http://dx.doi.org/10.1074/jbc.RA118.002139

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