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Uncoupling fork speed and origin activity to identify the primary cause of replicative stress phenotypes

In growing cells, DNA replication precedes mitotic cell division to transmit genetic information to the next generation. The slowing or stalling of DNA replication forks at natural or exogenous obstacles causes “replicative stress” that promotes genomic instability and affects cellular fitness. Repl...

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Detalles Bibliográficos
Autores principales:	Rodriguez-Acebes, Sara, Mourón, Silvana, Méndez, Juan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	DNA and Chromosomes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102153/ https://www.ncbi.nlm.nih.gov/pubmed/29959228 http://dx.doi.org/10.1074/jbc.RA118.003740

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