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Heart rate elevations during early sepsis predict death in fluid-resuscitated rats with fecal peritonitis
BACKGROUND: In sepsis, early outcome prediction would allow investigation of both adaptive mechanisms underlying survival and maladaptive mechanisms resulting in death. The aim of this study was to test whether early changes in heart rate monitored by telemetry could predict outcome in a long-term r...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102166/ https://www.ncbi.nlm.nih.gov/pubmed/30128907 http://dx.doi.org/10.1186/s40635-018-0190-5 |
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author | Rudiger, Alain Jeger, Victor Arrigo, Mattia Schaer, Christian A. Hildenbrand, Florian F. Arras, Margarete Seifert, Burkhardt Singer, Mervyn Schoedon, Gabriele Spahn, Donat R. Bettex, Dominique |
author_facet | Rudiger, Alain Jeger, Victor Arrigo, Mattia Schaer, Christian A. Hildenbrand, Florian F. Arras, Margarete Seifert, Burkhardt Singer, Mervyn Schoedon, Gabriele Spahn, Donat R. Bettex, Dominique |
author_sort | Rudiger, Alain |
collection | PubMed |
description | BACKGROUND: In sepsis, early outcome prediction would allow investigation of both adaptive mechanisms underlying survival and maladaptive mechanisms resulting in death. The aim of this study was to test whether early changes in heart rate monitored by telemetry could predict outcome in a long-term rat model of fecal peritonitis. METHODS: Male Wistar rats (n = 24) were instrumented with a central venous line for administration of fluids, antibiotics and analgesics. A telemetry transmitter continuously collected electrocardiogram signals. Sepsis was induced by intraperitoneal injection of fecal slurry, and the animals were observed for 48 h. Additional animals underwent arterial cannulation at baseline (n = 9), 4 h (n = 16), or 24 h (n = 6) for physiology and laboratory measurements. RESULTS: 48-h mortality was 33% (8/24), with all deaths occurring between 4 and 22 h. Septic animals were characterized by lethargy, fever, tachycardia, positive blood cultures, and elevated cytokine (IL-1, IL-6, TNF alpha) levels. An increase in heart rate ≥ 50 bpm during the first 4 h of sepsis predicted death with sensitivity and specificity of 88% (p = 0.001). CONCLUSIONS: In this long-term rat sepsis model, prognostication could be made early by telemetry-monitored changes in heart rate. This model enables the study of underlying mechanisms and the assessment of any differential effects of novel therapies in predicted survivors or non-survivors. |
format | Online Article Text |
id | pubmed-6102166 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-61021662018-09-11 Heart rate elevations during early sepsis predict death in fluid-resuscitated rats with fecal peritonitis Rudiger, Alain Jeger, Victor Arrigo, Mattia Schaer, Christian A. Hildenbrand, Florian F. Arras, Margarete Seifert, Burkhardt Singer, Mervyn Schoedon, Gabriele Spahn, Donat R. Bettex, Dominique Intensive Care Med Exp Research BACKGROUND: In sepsis, early outcome prediction would allow investigation of both adaptive mechanisms underlying survival and maladaptive mechanisms resulting in death. The aim of this study was to test whether early changes in heart rate monitored by telemetry could predict outcome in a long-term rat model of fecal peritonitis. METHODS: Male Wistar rats (n = 24) were instrumented with a central venous line for administration of fluids, antibiotics and analgesics. A telemetry transmitter continuously collected electrocardiogram signals. Sepsis was induced by intraperitoneal injection of fecal slurry, and the animals were observed for 48 h. Additional animals underwent arterial cannulation at baseline (n = 9), 4 h (n = 16), or 24 h (n = 6) for physiology and laboratory measurements. RESULTS: 48-h mortality was 33% (8/24), with all deaths occurring between 4 and 22 h. Septic animals were characterized by lethargy, fever, tachycardia, positive blood cultures, and elevated cytokine (IL-1, IL-6, TNF alpha) levels. An increase in heart rate ≥ 50 bpm during the first 4 h of sepsis predicted death with sensitivity and specificity of 88% (p = 0.001). CONCLUSIONS: In this long-term rat sepsis model, prognostication could be made early by telemetry-monitored changes in heart rate. This model enables the study of underlying mechanisms and the assessment of any differential effects of novel therapies in predicted survivors or non-survivors. Springer International Publishing 2018-08-20 /pmc/articles/PMC6102166/ /pubmed/30128907 http://dx.doi.org/10.1186/s40635-018-0190-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Research Rudiger, Alain Jeger, Victor Arrigo, Mattia Schaer, Christian A. Hildenbrand, Florian F. Arras, Margarete Seifert, Burkhardt Singer, Mervyn Schoedon, Gabriele Spahn, Donat R. Bettex, Dominique Heart rate elevations during early sepsis predict death in fluid-resuscitated rats with fecal peritonitis |
title | Heart rate elevations during early sepsis predict death in fluid-resuscitated rats with fecal peritonitis |
title_full | Heart rate elevations during early sepsis predict death in fluid-resuscitated rats with fecal peritonitis |
title_fullStr | Heart rate elevations during early sepsis predict death in fluid-resuscitated rats with fecal peritonitis |
title_full_unstemmed | Heart rate elevations during early sepsis predict death in fluid-resuscitated rats with fecal peritonitis |
title_short | Heart rate elevations during early sepsis predict death in fluid-resuscitated rats with fecal peritonitis |
title_sort | heart rate elevations during early sepsis predict death in fluid-resuscitated rats with fecal peritonitis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102166/ https://www.ncbi.nlm.nih.gov/pubmed/30128907 http://dx.doi.org/10.1186/s40635-018-0190-5 |
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