Residual Dipolar Couplings in Structure Determination of Natural Products

ABSTRACT: The determination of natural products stereochemistry remains a formidable task. Residual dipolar couplings (RDCs) induced by anisotropic media are a powerful tool for determination of the stereochemistry of organic molecule in solution. This review will provide a short introduction on RDC...

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Detalles Bibliográficos
Autores principales: Li, Gao-Wei, Liu, Han, Qiu, Feng, Wang, Xiao-Juan, Lei, Xin-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102172/
https://www.ncbi.nlm.nih.gov/pubmed/29943349
http://dx.doi.org/10.1007/s13659-018-0174-x
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author Li, Gao-Wei
Liu, Han
Qiu, Feng
Wang, Xiao-Juan
Lei, Xin-Xiang
author_facet Li, Gao-Wei
Liu, Han
Qiu, Feng
Wang, Xiao-Juan
Lei, Xin-Xiang
author_sort Li, Gao-Wei
collection PubMed
description ABSTRACT: The determination of natural products stereochemistry remains a formidable task. Residual dipolar couplings (RDCs) induced by anisotropic media are a powerful tool for determination of the stereochemistry of organic molecule in solution. This review will provide a short introduction on RDCs-based methodology for the structural elucidation of natural products. Special attention is given to the current availability of alignment media in organic solvents. The applications of RDCs for structural analysis of some examples of natural products were discussed and summarized. GRAPHICAL ABSTRACT: This review provides a short introduction on RDCs-based methodology for the structural elucidation of natural products. Special attention is given to the current availability of alignment media in organic solvents. The applications of RDCs for structural analysis of some examples of natural products were discussed and summarized. [Image: see text]
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spelling pubmed-61021722018-08-27 Residual Dipolar Couplings in Structure Determination of Natural Products Li, Gao-Wei Liu, Han Qiu, Feng Wang, Xiao-Juan Lei, Xin-Xiang Nat Prod Bioprospect Review ABSTRACT: The determination of natural products stereochemistry remains a formidable task. Residual dipolar couplings (RDCs) induced by anisotropic media are a powerful tool for determination of the stereochemistry of organic molecule in solution. This review will provide a short introduction on RDCs-based methodology for the structural elucidation of natural products. Special attention is given to the current availability of alignment media in organic solvents. The applications of RDCs for structural analysis of some examples of natural products were discussed and summarized. GRAPHICAL ABSTRACT: This review provides a short introduction on RDCs-based methodology for the structural elucidation of natural products. Special attention is given to the current availability of alignment media in organic solvents. The applications of RDCs for structural analysis of some examples of natural products were discussed and summarized. [Image: see text] Springer Singapore 2018-06-25 /pmc/articles/PMC6102172/ /pubmed/29943349 http://dx.doi.org/10.1007/s13659-018-0174-x Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Li, Gao-Wei
Liu, Han
Qiu, Feng
Wang, Xiao-Juan
Lei, Xin-Xiang
Residual Dipolar Couplings in Structure Determination of Natural Products
title Residual Dipolar Couplings in Structure Determination of Natural Products
title_full Residual Dipolar Couplings in Structure Determination of Natural Products
title_fullStr Residual Dipolar Couplings in Structure Determination of Natural Products
title_full_unstemmed Residual Dipolar Couplings in Structure Determination of Natural Products
title_short Residual Dipolar Couplings in Structure Determination of Natural Products
title_sort residual dipolar couplings in structure determination of natural products
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102172/
https://www.ncbi.nlm.nih.gov/pubmed/29943349
http://dx.doi.org/10.1007/s13659-018-0174-x
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AT wangxiaojuan residualdipolarcouplingsinstructuredeterminationofnaturalproducts
AT leixinxiang residualdipolarcouplingsinstructuredeterminationofnaturalproducts

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