Cargando…

Multi-scale, whole-system models of liver metabolic adaptation to fat and sugar in non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) is a serious public health issue associated with high fat, high sugar diets. However, the molecular mechanisms mediating NAFLD pathogenesis are only partially understood. Here we adopt an iterative multi-scale, systems biology approach coupled to in vitro ex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maldonado, Elaina M., Fisher, Ciarán P., Mazzatti, Dawn J., Barber, Amy L., Tindall, Marcus J., Plant, Nicholas J., Kierzek, Andrzej M., Moore, J. Bernadette
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102210/ https://www.ncbi.nlm.nih.gov/pubmed/30131870 http://dx.doi.org/10.1038/s41540-018-0070-3

Ejemplares similares

Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics
por: Maldonado, Elaina M., et al.
Publicado: (2017)

QSSPN: dynamic simulation of molecular interaction networks describing gene regulation, signalling and whole-cell metabolism in human cells
por: Fisher, Ciarán P., et al.
Publicado: (2013)

The Role of Dietary Sugars and De novo Lipogenesis in Non-Alcoholic Fatty Liver Disease
por: Moore, J. Bernadette, et al.
Publicado: (2014)

Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease
por: Spanos, Christos, et al.
Publicado: (2018)

Non-alcoholic fatty liver disease (NAFLD): a tale of fat and sugar?
por: Longato, Lisa
Publicado: (2013)

Correction to: Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease
por: Spanos, Christos, et al.
Publicado: (2018)

Diet-Induced Models of Non-Alcoholic Fatty Liver Disease: Food for Thought on Sugar, Fat, and Cholesterol
por: Eng, James M., et al.
Publicado: (2021)

Fat and Sugar—A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease
por: Simoes, Ines C.M., et al.
Publicado: (2019)

Sugar in the Liver
Publicado: (1858)

Fat, Sugar, Whole Grains and Heart Disease: 50 Years of Confusion
por: Temple, Norman J.
Publicado: (2018)

Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver
por: Dongiovanni, P., et al.
Publicado: (2017)

Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars
por: Luukkonen, Panu K., et al.
Publicado: (2018)

Sugar-sweetened beverages, low/no-calorie beverages, fruit juice and non-alcoholic fatty liver disease defined by fatty liver index: the SWEET project
por: Naomi, Novita D., et al.
Publicado: (2023)

Efficacy of dietary and physical activity intervention in non-alcoholic fatty liver disease: a systematic review
por: Kenneally, Susan, et al.
Publicado: (2017)

Estimation of Liver Fat by FibroScan in Patients With Nonalcoholic Fatty Liver Disease
por: Shrestha, Rupesh, et al.
Publicado: (2021)

GOS Ameliorates Nonalcoholic Fatty Liver Disease Induced by High Fat and High Sugar Diet through Lipid Metabolism and Intestinal Microbes
por: Qiu, Shuting, et al.
Publicado: (2022)

Study on the effect of different types of sugar on lipid deposition in goose fatty liver
por: Wei, Rongxue, et al.
Publicado: (2022)

Glucosamine Improves Non-Alcoholic Fatty Liver Disease Induced by High-Fat and High-Sugar Diet through Regulating Intestinal Barrier Function, Liver Inflammation, and Lipid Metabolism
por: Li, Feng, et al.
Publicado: (2023)

Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids
por: Orešič, Matej, et al.
Publicado: (2013)

Noninvasive Quantitative Detection Methods of Liver Fat Content in Nonalcoholic Fatty Liver Disease
por: Lv, Shujing, et al.
Publicado: (2018)

Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss
por: Hallsworth, Kate, et al.
Publicado: (2011)

Independent effects of diet and exercise training on fat oxidation in non-alcoholic fatty liver disease
por: Croci, Ilaria, et al.
Publicado: (2016)

Is Hepatocellular Carcinoma in Fatty Liver Different to Non-Fatty Liver?
por: Nguyen, Xuan-vinh Kevin, et al.
Publicado: (2022)

Overeating Saturated Fat Promotes Fatty Liver and Ceramides Compared With Polyunsaturated Fat: A Randomized Trial
por: Rosqvist, Fredrik, et al.
Publicado: (2019)

THE RELATION BETWEEN THE FAT CONTENT OF THE BILE AND FATTY CHANGES IN THE LIVER
por: Le Count, Edwin R., et al.
Publicado: (1914)

Assessment of high-fat-diet-induced fatty liver in medaka
por: Fujisawa, Koichi, et al.
Publicado: (2018)

Visceral-to-Subcutaneous Abdominal Fat Ratio Is Associated with Nonalcoholic Fatty Liver Disease and Liver Fibrosis
por: Jung, Chan-Hee, et al.
Publicado: (2020)

Combined metabolic activators therapy ameliorates liver fat in nonalcoholic fatty liver disease patients
por: Zeybel, Mujdat, et al.
Publicado: (2021)

Improving the accuracy of fatty liver index to reflect liver fat content with predictive regression modelling
por: Asaturyan, Hykoush A., et al.
Publicado: (2022)

Sugar Alcohols Have a Key Role in Pathogenesis of Chronic Liver Disease and Hepatocellular Carcinoma in Whole Blood and Liver Tissues
por: Ismail, Israa T., et al.
Publicado: (2020)

The association of pericardial fat and peri-aortic fat with severity of nonalcoholic fatty liver disease
por: Lee, Chun-Wei, et al.
Publicado: (2022)

Associations Between Intake of Sugar‐Containing Beverages in Infancy With Liver Fat Accumulation at School Age
por: Geurtsen, Madelon L., et al.
Publicado: (2021)

The Influence of Dietary Fat on Liver Fat Accumulation
por: Green, Charlotte J., et al.
Publicado: (2014)

The Calculation and Evaluation of an Ultrasound-Estimated Fat Fraction in Non-Alcoholic Fatty Liver Disease and Metabolic-Associated Fatty Liver Disease
por: Kaposi, Pál Novák, et al.
Publicado: (2023)

Intake of Nutrients, Fiber, and Sugar in Patients with Nonalcoholic Fatty Liver Disease in Comparison to Healthy Individuals
por: Zolfaghari, Hamid, et al.
Publicado: (2016)

The Liver, Viewed as a Sugar-Producer
por: Howell, William
Publicado: (1855)

The Impact and Burden of Dietary Sugars on the Liver
por: Huneault, Helaina E., et al.
Publicado: (2023)

Where does liver fat go? A possible molecular link between fatty liver and diabetes
por: Kikuchi, Akihiro, et al.
Publicado: (2016)

Variation in fat content between liver lobes and comparison with histopathological scores in dairy cows with fatty liver
por: Gerspach, C., et al.
Publicado: (2017)

Lipoprotein Insulin Resistance Index Reflects Liver Fat Content in Patients With Nonalcoholic Fatty Liver Disease
por: Vittal, Anusha, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_51vq3f3gbfja5b0e6ofvi9o3oc