α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies

Aggregation of α-synuclein, the hallmark of α-synucleinopathies such as Parkinson’s disease, occurs in various glycosphingolipidoses. Although α-synuclein aggregation correlates with deficiencies in the lysosomal degradation of glycosphingolipids (GSL), the mechanism(s) involved in this aggregation...

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Detalles Bibliográficos
Autores principales: Abdelkarim, Hazem, Marshall, Michael S., Scesa, Giuseppe, Smith, Rachael A., Rue, Emily, Marshall, Jeffrey, Elackattu, Vince, Stoskute, Monika, Issa, Yazan, Santos, Marta, Nguyen, Duc, Hauck, Zane, van Breemen, Richard, Celej, Maria S., Gaponenko, Vadim, Bongarzone, Ernesto R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102231/
https://www.ncbi.nlm.nih.gov/pubmed/30127535
http://dx.doi.org/10.1038/s41598-018-30808-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102231/
https://www.ncbi.nlm.nih.gov/pubmed/30127535
http://dx.doi.org/10.1038/s41598-018-30808-9

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