Comparison of Simulated Keratometry and Total Refractive Power for Keratoconus According to the Stage of Amsler-Krumeich Classification

This study was aimed to assess the simulated keratometry (Sim K) and the total corneal refractive power (TCRP) in eyes with keratoconus with respect to the Amsler-Krumeich classification. We enrolled 100 eyes of 100 keratoconic patients and 25 age-matched normal eyes. The Sim K and TCRP were measured with a rotating Scheimpflug system (Pentacam HR, Oculus). The differences between Sim K and TCRP in the keratoconus group were significantly larger than those in the control group (p < 0.001). The differences between Sim K and TCRP became larger in the progressive stages of the disease (p = 0.191 for stage 1, p = 0.008 for stage 2, p < 0.001 for stage 3, p < 0.001 for stage 4). We found a significant correlation of Sim K with the differences between Sim K and TCRP in keratoconic patients (r = 0.497, p < 0.001). The differences between Sim K and TCRP for keratoconus were significantly larger than those for normal eyes, and the differences between Sim K and TCRP tended to become larger in the progressive stages of the disease. It is suggested that the Sim K readings overestimate the TCRP, especially in advanced keratoconus, and that this discrepancy is a possible source of a hyperopic refractive error after cataract surgery.