ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis

Ankylosing spondylitis (AS) is a prototypical sero-negative autoimmune disease that affects millions worldwide. Single nucleotide polymorphisms in the Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) gene have been linked to AS via GWAS studies, however, the exact mechanism as to how ERAP1 contributes...

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Detalles Bibliográficos
Autores principales: Pepelyayeva, Yuliya, Rastall, David P. W., Aldhamen, Yasser A., O’Connell, Patrick, Raehtz, Sandra, Alyaqoub, Fadel S., Blake, Maja K., Raedy, Ashley M., Angarita, Ariana M., Abbas, Abdulraouf M., Pereira-Hicks, Cristiane N., Roosa, Sarah G., McCabe, Laura, Amalfitano, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102283/
https://www.ncbi.nlm.nih.gov/pubmed/30127455
http://dx.doi.org/10.1038/s41598-018-30159-5

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