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Differentiating cognitive or motor dimensions associated with the perception of fall-related self-efficacy in Parkinson’s disease

In Parkinson’s disease (PD), concurrent declines in cognitive and motor domain function can severely limit an individual’s ability to conduct daily tasks. Current diagnostic methods, however, lack precision in differentiating domain-specific contributions of cognitive or motor impairments based on a...

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Autores principales: Chomiak, Taylor, Watts, Alexander, Burt, Jacqueline, Camicioli, Richard, Tan, Sun Nee, McKeown, Martin J., Hu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102294/
https://www.ncbi.nlm.nih.gov/pubmed/30155514
http://dx.doi.org/10.1038/s41531-018-0059-z
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author Chomiak, Taylor
Watts, Alexander
Burt, Jacqueline
Camicioli, Richard
Tan, Sun Nee
McKeown, Martin J.
Hu, Bin
author_facet Chomiak, Taylor
Watts, Alexander
Burt, Jacqueline
Camicioli, Richard
Tan, Sun Nee
McKeown, Martin J.
Hu, Bin
author_sort Chomiak, Taylor
collection PubMed
description In Parkinson’s disease (PD), concurrent declines in cognitive and motor domain function can severely limit an individual’s ability to conduct daily tasks. Current diagnostic methods, however, lack precision in differentiating domain-specific contributions of cognitive or motor impairments based on a patients’ clinical manifestation. Fear of falling (FOF) is a common clinical manifestation among the elderly, in which both cognitive and motor impairments can lead to significant barriers to a patients’ physical and social activities. The present study evaluated whether a set of analytical and machine-learning approaches could be used to help delineate boundary conditions and separate cognitive and motor contributions to a patient’s own perception of self-efficacy and FOF. Cognitive and motor clinical scores, in conjunction with FOF, were collected from 57 Parkinson’s patients during a multi-center rehabilitation intervention trial. Statistical methodology was used to extract a subset of uncorrelated cognitive and motor components associated with cognitive and motor predictors, which were then used to independently identify and visualize cognitive and motor dimensions associated with FOF. We found that a central cognitive process, extracted from tests of executive, attentional, and visuoperceptive function, was a unique and significant independent cognitive predictor of FOF in PD. In addition, we provide evidence that the approaches described here may be used to computationally discern specific types of FOF based on separable cognitive or motor models. Our results are consistent with a contemporary model that the deterioration of a central cognitive mechanism that modulates self-efficacy also plays a critical role in FOF in PD.
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spelling pubmed-61022942018-08-28 Differentiating cognitive or motor dimensions associated with the perception of fall-related self-efficacy in Parkinson’s disease Chomiak, Taylor Watts, Alexander Burt, Jacqueline Camicioli, Richard Tan, Sun Nee McKeown, Martin J. Hu, Bin NPJ Parkinsons Dis Article In Parkinson’s disease (PD), concurrent declines in cognitive and motor domain function can severely limit an individual’s ability to conduct daily tasks. Current diagnostic methods, however, lack precision in differentiating domain-specific contributions of cognitive or motor impairments based on a patients’ clinical manifestation. Fear of falling (FOF) is a common clinical manifestation among the elderly, in which both cognitive and motor impairments can lead to significant barriers to a patients’ physical and social activities. The present study evaluated whether a set of analytical and machine-learning approaches could be used to help delineate boundary conditions and separate cognitive and motor contributions to a patient’s own perception of self-efficacy and FOF. Cognitive and motor clinical scores, in conjunction with FOF, were collected from 57 Parkinson’s patients during a multi-center rehabilitation intervention trial. Statistical methodology was used to extract a subset of uncorrelated cognitive and motor components associated with cognitive and motor predictors, which were then used to independently identify and visualize cognitive and motor dimensions associated with FOF. We found that a central cognitive process, extracted from tests of executive, attentional, and visuoperceptive function, was a unique and significant independent cognitive predictor of FOF in PD. In addition, we provide evidence that the approaches described here may be used to computationally discern specific types of FOF based on separable cognitive or motor models. Our results are consistent with a contemporary model that the deterioration of a central cognitive mechanism that modulates self-efficacy also plays a critical role in FOF in PD. Nature Publishing Group UK 2018-08-20 /pmc/articles/PMC6102294/ /pubmed/30155514 http://dx.doi.org/10.1038/s41531-018-0059-z Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Chomiak, Taylor
Watts, Alexander
Burt, Jacqueline
Camicioli, Richard
Tan, Sun Nee
McKeown, Martin J.
Hu, Bin
Differentiating cognitive or motor dimensions associated with the perception of fall-related self-efficacy in Parkinson’s disease
title Differentiating cognitive or motor dimensions associated with the perception of fall-related self-efficacy in Parkinson’s disease
title_full Differentiating cognitive or motor dimensions associated with the perception of fall-related self-efficacy in Parkinson’s disease
title_fullStr Differentiating cognitive or motor dimensions associated with the perception of fall-related self-efficacy in Parkinson’s disease
title_full_unstemmed Differentiating cognitive or motor dimensions associated with the perception of fall-related self-efficacy in Parkinson’s disease
title_short Differentiating cognitive or motor dimensions associated with the perception of fall-related self-efficacy in Parkinson’s disease
title_sort differentiating cognitive or motor dimensions associated with the perception of fall-related self-efficacy in parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102294/
https://www.ncbi.nlm.nih.gov/pubmed/30155514
http://dx.doi.org/10.1038/s41531-018-0059-z
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