Contribution of BH3-domain and Transmembrane-domain to the Activity and Interaction of the Pore-forming Bcl-2 Proteins Bok, Bak, and Bax

Central to intrinsic apoptosis signaling is the release of cytochrome c from mitochondria, which depends on the pro-apoptotic effector proteins Bax, Bak or Bok. These pore-forming effector proteins share four Bcl-2 homology (BH) domains, a functionally essential and conserved sequence of hydrophobic...

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Detalles Bibliográficos
Autores principales: Stehle, Daniel, Grimm, Melanie, Einsele-Scholz, Stephanie, Ladwig, Friederike, Johänning, Janina, Fischer, Gerd, Gillissen, Bernhard, Schulze-Osthoff, Klaus, Essmann, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102298/
https://www.ncbi.nlm.nih.gov/pubmed/30127460
http://dx.doi.org/10.1038/s41598-018-30603-6

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