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A Metabolism-Based Synergy for Total Coumarin Extract of Radix Angelicae Dahuricae and Ligustrazine on Migraine Treatment in Rats

Radix Angelicae dahuricae, containing coumarins, which might affect cytochrome P450 enzyme (CYP450) activity, has been co-administered with ligustrazine, a substrate of CYP450s, for the clinical treatment of migraine. However, whether a pharmacokinetic-based synergy exists between Radix Angelicae da...

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Detalles Bibliográficos
Autores principales:	Feng, Shan, He, Xin, Zhong, Peiru, Zhao, Jinyi, Huang, Cong, Hu, Zhuohan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102536/ https://www.ncbi.nlm.nih.gov/pubmed/29693578 http://dx.doi.org/10.3390/molecules23051004

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