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Bioactivity-Guided Isolation of Antimicrobial and Antioxidant Metabolites from the Mushroom Tapinella atrotomentosa

Bioassay-guided fractionation of the chloroform extract of Tapinella atrotomentosa led to the isolation of four secondary metabolites 1–4. Two of the compounds are lactones—osmundalactone (1) and 5-hydroxy-hex-2-en-4-olide (2)—while 3 and 4 were identified as terphenyl quinones, spiromentins C and B...

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Autores principales: Béni, Zoltán, Dékány, Miklós, Kovács, Bernadett, Csupor-Löffler, Boglárka, Zomborszki, Zoltán Péter, Kerekes, Erika, Szekeres, András, Urbán, Edit, Hohmann, Judit, Ványolós, Attila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102582/
https://www.ncbi.nlm.nih.gov/pubmed/29734648
http://dx.doi.org/10.3390/molecules23051082
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author Béni, Zoltán
Dékány, Miklós
Kovács, Bernadett
Csupor-Löffler, Boglárka
Zomborszki, Zoltán Péter
Kerekes, Erika
Szekeres, András
Urbán, Edit
Hohmann, Judit
Ványolós, Attila
author_facet Béni, Zoltán
Dékány, Miklós
Kovács, Bernadett
Csupor-Löffler, Boglárka
Zomborszki, Zoltán Péter
Kerekes, Erika
Szekeres, András
Urbán, Edit
Hohmann, Judit
Ványolós, Attila
author_sort Béni, Zoltán
collection PubMed
description Bioassay-guided fractionation of the chloroform extract of Tapinella atrotomentosa led to the isolation of four secondary metabolites 1–4. Two of the compounds are lactones—osmundalactone (1) and 5-hydroxy-hex-2-en-4-olide (2)—while 3 and 4 were identified as terphenyl quinones, spiromentins C and B, respectively. The structures of the compounds were established on the basis of NMR and MS spectroscopic analysis. The isolated fungal metabolites were evaluated for their antibacterial activities against several Gram-positive and negative bacteria. In addition, their synergistic effect with cefuroxime against methicillin-resistant Staphylococcus aureus (MRSA) was also evaluated. Compounds 1–3 proved to possess significant antibacterial activity against multiresistant Acinetobacter baumannii and extended-spectrum β-lactamase (ESBL)-producing Escherichia coli. The investigation of the antioxidant effect of the isolated compounds in DPPH and ORAC assays revealed that spiromentins C (3) and B (4) have remarkable antioxidant activity.
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spelling pubmed-61025822018-11-13 Bioactivity-Guided Isolation of Antimicrobial and Antioxidant Metabolites from the Mushroom Tapinella atrotomentosa Béni, Zoltán Dékány, Miklós Kovács, Bernadett Csupor-Löffler, Boglárka Zomborszki, Zoltán Péter Kerekes, Erika Szekeres, András Urbán, Edit Hohmann, Judit Ványolós, Attila Molecules Article Bioassay-guided fractionation of the chloroform extract of Tapinella atrotomentosa led to the isolation of four secondary metabolites 1–4. Two of the compounds are lactones—osmundalactone (1) and 5-hydroxy-hex-2-en-4-olide (2)—while 3 and 4 were identified as terphenyl quinones, spiromentins C and B, respectively. The structures of the compounds were established on the basis of NMR and MS spectroscopic analysis. The isolated fungal metabolites were evaluated for their antibacterial activities against several Gram-positive and negative bacteria. In addition, their synergistic effect with cefuroxime against methicillin-resistant Staphylococcus aureus (MRSA) was also evaluated. Compounds 1–3 proved to possess significant antibacterial activity against multiresistant Acinetobacter baumannii and extended-spectrum β-lactamase (ESBL)-producing Escherichia coli. The investigation of the antioxidant effect of the isolated compounds in DPPH and ORAC assays revealed that spiromentins C (3) and B (4) have remarkable antioxidant activity. MDPI 2018-05-04 /pmc/articles/PMC6102582/ /pubmed/29734648 http://dx.doi.org/10.3390/molecules23051082 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Béni, Zoltán
Dékány, Miklós
Kovács, Bernadett
Csupor-Löffler, Boglárka
Zomborszki, Zoltán Péter
Kerekes, Erika
Szekeres, András
Urbán, Edit
Hohmann, Judit
Ványolós, Attila
Bioactivity-Guided Isolation of Antimicrobial and Antioxidant Metabolites from the Mushroom Tapinella atrotomentosa
title Bioactivity-Guided Isolation of Antimicrobial and Antioxidant Metabolites from the Mushroom Tapinella atrotomentosa
title_full Bioactivity-Guided Isolation of Antimicrobial and Antioxidant Metabolites from the Mushroom Tapinella atrotomentosa
title_fullStr Bioactivity-Guided Isolation of Antimicrobial and Antioxidant Metabolites from the Mushroom Tapinella atrotomentosa
title_full_unstemmed Bioactivity-Guided Isolation of Antimicrobial and Antioxidant Metabolites from the Mushroom Tapinella atrotomentosa
title_short Bioactivity-Guided Isolation of Antimicrobial and Antioxidant Metabolites from the Mushroom Tapinella atrotomentosa
title_sort bioactivity-guided isolation of antimicrobial and antioxidant metabolites from the mushroom tapinella atrotomentosa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102582/
https://www.ncbi.nlm.nih.gov/pubmed/29734648
http://dx.doi.org/10.3390/molecules23051082
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