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Discovery of Potential Inhibitors of Squalene Synthase from Traditional Chinese Medicine Based on Virtual Screening and In Vitro Evaluation of Lipid-Lowering Effect

Squalene synthase (SQS), a key downstream enzyme involved in the cholesterol biosynthetic pathway, plays an important role in treating hyperlipidemia. Compared to statins, SQS inhibitors have shown a very significant lipid-lowering effect and do not cause myotoxicity. Thus, the paper aims to discove...

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Detalles Bibliográficos
Autores principales:	Chen, Yankun, Chen, Xi, Luo, Ganggang, Zhang, Xu, Lu, Fang, Qiao, Liansheng, He, Wenjing, Li, Gongyu, Zhang, Yanling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102583/ https://www.ncbi.nlm.nih.gov/pubmed/29710800 http://dx.doi.org/10.3390/molecules23051040

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