Synthesis of a Novel Series of Amino Acid Prodrugs Based on Thienopyridine Scaffolds and Evaluation of Their Antiplatelet Activity

The thienopyridines class of drugs used as P2Y(12) receptor antagonists plays a vital role in antiplatelet therapy. To further optimized this compound class, we designed and synthesized a series of amino acid prodrugs of 2-hydroxytetrahydrothienopyridine. All compounds were then evaluated for their...

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Detalles Bibliográficos
Autores principales: Lu, Nan, Li, Lingjun, Zheng, Xuemin, Zhang, Shijun, Li, Yuquan, Yuan, Jing, Wei, Qunchao, Xu, Youjun, Meng, Fancui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102589/
https://www.ncbi.nlm.nih.gov/pubmed/29710801
http://dx.doi.org/10.3390/molecules23051041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102589/
https://www.ncbi.nlm.nih.gov/pubmed/29710801
http://dx.doi.org/10.3390/molecules23051041

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