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A Case of Paraneoplastic Limbic Encephalitis in a Patient with Invasive Thymoma with Anti-Glutamate Receptor Antibody-Positive Cerebrospinal Fluid: A Case Report

Background: Thymoma is known to cause autoimmune neuromuscular disease. However, anti-glutamate receptor antibody limbic encephalitis (LE) with thymoma is relatively rare. Case Presentation: A 68-year-old woman was admitted with progressive memory impairment and personality change. Brain magnetic re...

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Autores principales: Inoue, Takuya, Kanno, Ryuzo, Moriya, Arata, Nakamura, Koichiro, Watanabe, Yuzuru, Matsumura, Yuki, Suzuki, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102601/
https://www.ncbi.nlm.nih.gov/pubmed/29269707
http://dx.doi.org/10.5761/atcs.cr.17-00135
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author Inoue, Takuya
Kanno, Ryuzo
Moriya, Arata
Nakamura, Koichiro
Watanabe, Yuzuru
Matsumura, Yuki
Suzuki, Hiroyuki
author_facet Inoue, Takuya
Kanno, Ryuzo
Moriya, Arata
Nakamura, Koichiro
Watanabe, Yuzuru
Matsumura, Yuki
Suzuki, Hiroyuki
author_sort Inoue, Takuya
collection PubMed
description Background: Thymoma is known to cause autoimmune neuromuscular disease. However, anti-glutamate receptor antibody limbic encephalitis (LE) with thymoma is relatively rare. Case Presentation: A 68-year-old woman was admitted with progressive memory impairment and personality change. Brain magnetic resonance imaging (MRI) revealed high intensity in the bilateral limbic areas on T2-weighted fluid-attenuation inversion recovery (FLAIR) images. Chest computed tomography revealed a mass in the anterior mediastinum. Surgical resection of the tumor, which was consistent with a type B3 thymoma, resulted in clinical improvement. After surgery, the cerebrospinal fluid (CSF) was found to be positive for anti-N-methyl-D-aspartate (NMDA) type glutamate receptor antibodies. These findings led to the diagnosis of paraneoplastic LE (PLE) associated with thymoma. Conclusion: When a patient presents with neurologic symptoms of unknown origin, the possibility of LE accompanied by thymoma should be considered. Rapid treatment is desirable before the symptoms become irreversible.
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spelling pubmed-61026012018-08-23 A Case of Paraneoplastic Limbic Encephalitis in a Patient with Invasive Thymoma with Anti-Glutamate Receptor Antibody-Positive Cerebrospinal Fluid: A Case Report Inoue, Takuya Kanno, Ryuzo Moriya, Arata Nakamura, Koichiro Watanabe, Yuzuru Matsumura, Yuki Suzuki, Hiroyuki Ann Thorac Cardiovasc Surg Case Report Background: Thymoma is known to cause autoimmune neuromuscular disease. However, anti-glutamate receptor antibody limbic encephalitis (LE) with thymoma is relatively rare. Case Presentation: A 68-year-old woman was admitted with progressive memory impairment and personality change. Brain magnetic resonance imaging (MRI) revealed high intensity in the bilateral limbic areas on T2-weighted fluid-attenuation inversion recovery (FLAIR) images. Chest computed tomography revealed a mass in the anterior mediastinum. Surgical resection of the tumor, which was consistent with a type B3 thymoma, resulted in clinical improvement. After surgery, the cerebrospinal fluid (CSF) was found to be positive for anti-N-methyl-D-aspartate (NMDA) type glutamate receptor antibodies. These findings led to the diagnosis of paraneoplastic LE (PLE) associated with thymoma. Conclusion: When a patient presents with neurologic symptoms of unknown origin, the possibility of LE accompanied by thymoma should be considered. Rapid treatment is desirable before the symptoms become irreversible. The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery 2017-12-20 2018 /pmc/articles/PMC6102601/ /pubmed/29269707 http://dx.doi.org/10.5761/atcs.cr.17-00135 Text en ©2018 Annals of Thoracic and Cardiovascular Surgery http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NonDerivatives International License (http://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Case Report
Inoue, Takuya
Kanno, Ryuzo
Moriya, Arata
Nakamura, Koichiro
Watanabe, Yuzuru
Matsumura, Yuki
Suzuki, Hiroyuki
A Case of Paraneoplastic Limbic Encephalitis in a Patient with Invasive Thymoma with Anti-Glutamate Receptor Antibody-Positive Cerebrospinal Fluid: A Case Report
title A Case of Paraneoplastic Limbic Encephalitis in a Patient with Invasive Thymoma with Anti-Glutamate Receptor Antibody-Positive Cerebrospinal Fluid: A Case Report
title_full A Case of Paraneoplastic Limbic Encephalitis in a Patient with Invasive Thymoma with Anti-Glutamate Receptor Antibody-Positive Cerebrospinal Fluid: A Case Report
title_fullStr A Case of Paraneoplastic Limbic Encephalitis in a Patient with Invasive Thymoma with Anti-Glutamate Receptor Antibody-Positive Cerebrospinal Fluid: A Case Report
title_full_unstemmed A Case of Paraneoplastic Limbic Encephalitis in a Patient with Invasive Thymoma with Anti-Glutamate Receptor Antibody-Positive Cerebrospinal Fluid: A Case Report
title_short A Case of Paraneoplastic Limbic Encephalitis in a Patient with Invasive Thymoma with Anti-Glutamate Receptor Antibody-Positive Cerebrospinal Fluid: A Case Report
title_sort case of paraneoplastic limbic encephalitis in a patient with invasive thymoma with anti-glutamate receptor antibody-positive cerebrospinal fluid: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102601/
https://www.ncbi.nlm.nih.gov/pubmed/29269707
http://dx.doi.org/10.5761/atcs.cr.17-00135
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