Cargando…

Immunoglobulin G Subclass 4-Related Lymphoplasmacytic Thoracic Aortitis in a Patient with Acute Type A Aortic Dissection

Immunoglobulin G subclass 4-related disease (IgG4-RD) is a recently recognized systemic inflammatory disease characterized by an elevated serum IgG4 level and an IgG4-positive lymphocyte infiltrate mainly in exocrine tissues. Previous reports documented IgG4-RD in several cardiovascular disorders. W...

Descripción completa

Detalles Bibliográficos
Autores principales: Uchida, Tetsuro, Hamasaki, Azumi, Kuroda, Yoshinori, Sadahiro, Mitsuaki, Tamazawa, Nobuyuki, Ohe, Rintaro, Yamakawa, Mitsunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102605/
https://www.ncbi.nlm.nih.gov/pubmed/29279461
http://dx.doi.org/10.5761/atcs.cr.17-00111
_version_ 1783349202203443200
author Uchida, Tetsuro
Hamasaki, Azumi
Kuroda, Yoshinori
Sadahiro, Mitsuaki
Tamazawa, Nobuyuki
Ohe, Rintaro
Yamakawa, Mitsunori
author_facet Uchida, Tetsuro
Hamasaki, Azumi
Kuroda, Yoshinori
Sadahiro, Mitsuaki
Tamazawa, Nobuyuki
Ohe, Rintaro
Yamakawa, Mitsunori
author_sort Uchida, Tetsuro
collection PubMed
description Immunoglobulin G subclass 4-related disease (IgG4-RD) is a recently recognized systemic inflammatory disease characterized by an elevated serum IgG4 level and an IgG4-positive lymphocyte infiltrate mainly in exocrine tissues. Previous reports documented IgG4-RD in several cardiovascular disorders. We present a case of type A aortic dissection associated with IgG4-RD. A 52-year-old man diagnosed with a type A aortic dissection was referred for surgical treatment. He underwent emergency hemiarch reconstruction with a prosthetic graft. His postoperative recovery was uncomplicated. Histopathologic examination of his aortic tissue showed marked adventitial thickening with fibrosis and an IgG4-positive plasma cell infiltrate. He was diagnosed with type A aortic dissection incidentally complicated by IgG4-RD. The relationship between IgG4-RD and the pathogenesis of aortic dissection remains unknown and requires further investigation.
format Online
Article
Text
id pubmed-6102605
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery
record_format MEDLINE/PubMed
spelling pubmed-61026052018-08-23 Immunoglobulin G Subclass 4-Related Lymphoplasmacytic Thoracic Aortitis in a Patient with Acute Type A Aortic Dissection Uchida, Tetsuro Hamasaki, Azumi Kuroda, Yoshinori Sadahiro, Mitsuaki Tamazawa, Nobuyuki Ohe, Rintaro Yamakawa, Mitsunori Ann Thorac Cardiovasc Surg Case Report Immunoglobulin G subclass 4-related disease (IgG4-RD) is a recently recognized systemic inflammatory disease characterized by an elevated serum IgG4 level and an IgG4-positive lymphocyte infiltrate mainly in exocrine tissues. Previous reports documented IgG4-RD in several cardiovascular disorders. We present a case of type A aortic dissection associated with IgG4-RD. A 52-year-old man diagnosed with a type A aortic dissection was referred for surgical treatment. He underwent emergency hemiarch reconstruction with a prosthetic graft. His postoperative recovery was uncomplicated. Histopathologic examination of his aortic tissue showed marked adventitial thickening with fibrosis and an IgG4-positive plasma cell infiltrate. He was diagnosed with type A aortic dissection incidentally complicated by IgG4-RD. The relationship between IgG4-RD and the pathogenesis of aortic dissection remains unknown and requires further investigation. The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery 2017-12-27 2018 /pmc/articles/PMC6102605/ /pubmed/29279461 http://dx.doi.org/10.5761/atcs.cr.17-00111 Text en ©2018 Annals of Thoracic and Cardiovascular Surgery http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NonDerivatives International License (http://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Case Report
Uchida, Tetsuro
Hamasaki, Azumi
Kuroda, Yoshinori
Sadahiro, Mitsuaki
Tamazawa, Nobuyuki
Ohe, Rintaro
Yamakawa, Mitsunori
Immunoglobulin G Subclass 4-Related Lymphoplasmacytic Thoracic Aortitis in a Patient with Acute Type A Aortic Dissection
title Immunoglobulin G Subclass 4-Related Lymphoplasmacytic Thoracic Aortitis in a Patient with Acute Type A Aortic Dissection
title_full Immunoglobulin G Subclass 4-Related Lymphoplasmacytic Thoracic Aortitis in a Patient with Acute Type A Aortic Dissection
title_fullStr Immunoglobulin G Subclass 4-Related Lymphoplasmacytic Thoracic Aortitis in a Patient with Acute Type A Aortic Dissection
title_full_unstemmed Immunoglobulin G Subclass 4-Related Lymphoplasmacytic Thoracic Aortitis in a Patient with Acute Type A Aortic Dissection
title_short Immunoglobulin G Subclass 4-Related Lymphoplasmacytic Thoracic Aortitis in a Patient with Acute Type A Aortic Dissection
title_sort immunoglobulin g subclass 4-related lymphoplasmacytic thoracic aortitis in a patient with acute type a aortic dissection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102605/
https://www.ncbi.nlm.nih.gov/pubmed/29279461
http://dx.doi.org/10.5761/atcs.cr.17-00111
work_keys_str_mv AT uchidatetsuro immunoglobulingsubclass4relatedlymphoplasmacyticthoracicaortitisinapatientwithacutetypeaaorticdissection
AT hamasakiazumi immunoglobulingsubclass4relatedlymphoplasmacyticthoracicaortitisinapatientwithacutetypeaaorticdissection
AT kurodayoshinori immunoglobulingsubclass4relatedlymphoplasmacyticthoracicaortitisinapatientwithacutetypeaaorticdissection
AT sadahiromitsuaki immunoglobulingsubclass4relatedlymphoplasmacyticthoracicaortitisinapatientwithacutetypeaaorticdissection
AT tamazawanobuyuki immunoglobulingsubclass4relatedlymphoplasmacyticthoracicaortitisinapatientwithacutetypeaaorticdissection
AT oherintaro immunoglobulingsubclass4relatedlymphoplasmacyticthoracicaortitisinapatientwithacutetypeaaorticdissection
AT yamakawamitsunori immunoglobulingsubclass4relatedlymphoplasmacyticthoracicaortitisinapatientwithacutetypeaaorticdissection