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Immunoglobulin G Subclass 4-Related Lymphoplasmacytic Thoracic Aortitis in a Patient with Acute Type A Aortic Dissection
Immunoglobulin G subclass 4-related disease (IgG4-RD) is a recently recognized systemic inflammatory disease characterized by an elevated serum IgG4 level and an IgG4-positive lymphocyte infiltrate mainly in exocrine tissues. Previous reports documented IgG4-RD in several cardiovascular disorders. W...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102605/ https://www.ncbi.nlm.nih.gov/pubmed/29279461 http://dx.doi.org/10.5761/atcs.cr.17-00111 |
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author | Uchida, Tetsuro Hamasaki, Azumi Kuroda, Yoshinori Sadahiro, Mitsuaki Tamazawa, Nobuyuki Ohe, Rintaro Yamakawa, Mitsunori |
author_facet | Uchida, Tetsuro Hamasaki, Azumi Kuroda, Yoshinori Sadahiro, Mitsuaki Tamazawa, Nobuyuki Ohe, Rintaro Yamakawa, Mitsunori |
author_sort | Uchida, Tetsuro |
collection | PubMed |
description | Immunoglobulin G subclass 4-related disease (IgG4-RD) is a recently recognized systemic inflammatory disease characterized by an elevated serum IgG4 level and an IgG4-positive lymphocyte infiltrate mainly in exocrine tissues. Previous reports documented IgG4-RD in several cardiovascular disorders. We present a case of type A aortic dissection associated with IgG4-RD. A 52-year-old man diagnosed with a type A aortic dissection was referred for surgical treatment. He underwent emergency hemiarch reconstruction with a prosthetic graft. His postoperative recovery was uncomplicated. Histopathologic examination of his aortic tissue showed marked adventitial thickening with fibrosis and an IgG4-positive plasma cell infiltrate. He was diagnosed with type A aortic dissection incidentally complicated by IgG4-RD. The relationship between IgG4-RD and the pathogenesis of aortic dissection remains unknown and requires further investigation. |
format | Online Article Text |
id | pubmed-6102605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery |
record_format | MEDLINE/PubMed |
spelling | pubmed-61026052018-08-23 Immunoglobulin G Subclass 4-Related Lymphoplasmacytic Thoracic Aortitis in a Patient with Acute Type A Aortic Dissection Uchida, Tetsuro Hamasaki, Azumi Kuroda, Yoshinori Sadahiro, Mitsuaki Tamazawa, Nobuyuki Ohe, Rintaro Yamakawa, Mitsunori Ann Thorac Cardiovasc Surg Case Report Immunoglobulin G subclass 4-related disease (IgG4-RD) is a recently recognized systemic inflammatory disease characterized by an elevated serum IgG4 level and an IgG4-positive lymphocyte infiltrate mainly in exocrine tissues. Previous reports documented IgG4-RD in several cardiovascular disorders. We present a case of type A aortic dissection associated with IgG4-RD. A 52-year-old man diagnosed with a type A aortic dissection was referred for surgical treatment. He underwent emergency hemiarch reconstruction with a prosthetic graft. His postoperative recovery was uncomplicated. Histopathologic examination of his aortic tissue showed marked adventitial thickening with fibrosis and an IgG4-positive plasma cell infiltrate. He was diagnosed with type A aortic dissection incidentally complicated by IgG4-RD. The relationship between IgG4-RD and the pathogenesis of aortic dissection remains unknown and requires further investigation. The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery 2017-12-27 2018 /pmc/articles/PMC6102605/ /pubmed/29279461 http://dx.doi.org/10.5761/atcs.cr.17-00111 Text en ©2018 Annals of Thoracic and Cardiovascular Surgery http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NonDerivatives International License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Case Report Uchida, Tetsuro Hamasaki, Azumi Kuroda, Yoshinori Sadahiro, Mitsuaki Tamazawa, Nobuyuki Ohe, Rintaro Yamakawa, Mitsunori Immunoglobulin G Subclass 4-Related Lymphoplasmacytic Thoracic Aortitis in a Patient with Acute Type A Aortic Dissection |
title | Immunoglobulin G Subclass 4-Related Lymphoplasmacytic Thoracic Aortitis in a Patient with Acute Type A Aortic Dissection |
title_full | Immunoglobulin G Subclass 4-Related Lymphoplasmacytic Thoracic Aortitis in a Patient with Acute Type A Aortic Dissection |
title_fullStr | Immunoglobulin G Subclass 4-Related Lymphoplasmacytic Thoracic Aortitis in a Patient with Acute Type A Aortic Dissection |
title_full_unstemmed | Immunoglobulin G Subclass 4-Related Lymphoplasmacytic Thoracic Aortitis in a Patient with Acute Type A Aortic Dissection |
title_short | Immunoglobulin G Subclass 4-Related Lymphoplasmacytic Thoracic Aortitis in a Patient with Acute Type A Aortic Dissection |
title_sort | immunoglobulin g subclass 4-related lymphoplasmacytic thoracic aortitis in a patient with acute type a aortic dissection |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102605/ https://www.ncbi.nlm.nih.gov/pubmed/29279461 http://dx.doi.org/10.5761/atcs.cr.17-00111 |
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