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Can components of the plasminogen activation system predict the outcome of kidney transplants?

Proteolytic and antiproteolytic enzymes play a critical role in the physiology and pathology of different stages of human life. One of the important members of the proteolytic family is the plasminogen activation system (PAS), which includes several elements crucial for this review: the 50 kDa glyco...

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Autores principales: Jankun, Jerzy, Khan, Omar A., Mostafa, Hesham I., Sindhwani, puneet, Skrzypczak-Jankun, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Polish Society of Experimental and Clinical Immunology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102612/
https://www.ncbi.nlm.nih.gov/pubmed/30135637
http://dx.doi.org/10.5114/ceji.2018.77394
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author Jankun, Jerzy
Khan, Omar A.
Mostafa, Hesham I.
Sindhwani, puneet
Skrzypczak-Jankun, Ewa
author_facet Jankun, Jerzy
Khan, Omar A.
Mostafa, Hesham I.
Sindhwani, puneet
Skrzypczak-Jankun, Ewa
author_sort Jankun, Jerzy
collection PubMed
description Proteolytic and antiproteolytic enzymes play a critical role in the physiology and pathology of different stages of human life. One of the important members of the proteolytic family is the plasminogen activation system (PAS), which includes several elements crucial for this review: the 50 kDa glycoprotein plasminogen activator inhibitor 1 (PAI-1) that inhibits tissue-type (tPA) and urokinase-type plasminogen activator (uPA). These two convert plasminogen into its active form named plasmin that can lyse a broad spectrum of proteins. Urokinase receptor (uPAR) is the binding site of uPA. This glycoprotein on the cell surface facilitates urokinase activation of plasminogen, creating high proteolytic activity close to the cell surface. PAS activities have been reported to predict the outcome of kidney transplants. However, reports on expression of PAS in kidney transplants seem to be controversial. On the one hand there are reports that impaired proteolytic activity leads to induction of chronic allograft nephropathy, while on the other hand treatment with uPA and tPA can restore function of acute renal transplants. In this comprehensive review we describe the complexity of the PAS as well as biological effects of the PAS on renal allografts, and provide a possible explanation of the reported controversy.
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spelling pubmed-61026122018-08-22 Can components of the plasminogen activation system predict the outcome of kidney transplants? Jankun, Jerzy Khan, Omar A. Mostafa, Hesham I. Sindhwani, puneet Skrzypczak-Jankun, Ewa Cent Eur J Immunol Review Paper Proteolytic and antiproteolytic enzymes play a critical role in the physiology and pathology of different stages of human life. One of the important members of the proteolytic family is the plasminogen activation system (PAS), which includes several elements crucial for this review: the 50 kDa glycoprotein plasminogen activator inhibitor 1 (PAI-1) that inhibits tissue-type (tPA) and urokinase-type plasminogen activator (uPA). These two convert plasminogen into its active form named plasmin that can lyse a broad spectrum of proteins. Urokinase receptor (uPAR) is the binding site of uPA. This glycoprotein on the cell surface facilitates urokinase activation of plasminogen, creating high proteolytic activity close to the cell surface. PAS activities have been reported to predict the outcome of kidney transplants. However, reports on expression of PAS in kidney transplants seem to be controversial. On the one hand there are reports that impaired proteolytic activity leads to induction of chronic allograft nephropathy, while on the other hand treatment with uPA and tPA can restore function of acute renal transplants. In this comprehensive review we describe the complexity of the PAS as well as biological effects of the PAS on renal allografts, and provide a possible explanation of the reported controversy. Polish Society of Experimental and Clinical Immunology 2018-06-30 2018 /pmc/articles/PMC6102612/ /pubmed/30135637 http://dx.doi.org/10.5114/ceji.2018.77394 Text en Copyright: © 2018 Polish Society of Experimental and Clinical Immunology http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Review Paper
Jankun, Jerzy
Khan, Omar A.
Mostafa, Hesham I.
Sindhwani, puneet
Skrzypczak-Jankun, Ewa
Can components of the plasminogen activation system predict the outcome of kidney transplants?
title Can components of the plasminogen activation system predict the outcome of kidney transplants?
title_full Can components of the plasminogen activation system predict the outcome of kidney transplants?
title_fullStr Can components of the plasminogen activation system predict the outcome of kidney transplants?
title_full_unstemmed Can components of the plasminogen activation system predict the outcome of kidney transplants?
title_short Can components of the plasminogen activation system predict the outcome of kidney transplants?
title_sort can components of the plasminogen activation system predict the outcome of kidney transplants?
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102612/
https://www.ncbi.nlm.nih.gov/pubmed/30135637
http://dx.doi.org/10.5114/ceji.2018.77394
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