Cargando…
Is oxidative stress measured by thiol/disulphide homeostasis status associated with prostate adenocarcinoma?
AIM OF THE STUDY: We aim to examine the relation between thiol/disulphide homeostasis and transrectal ultrasound guided prostate biopsy (TRUS-Bx) results and evaluate whether it was effective on the distinction of benign and malign prostate disease. MATERIAL AND METHODS: The study included 29 men hi...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Polish Society of Experimental and Clinical Immunology
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102614/ https://www.ncbi.nlm.nih.gov/pubmed/30135630 http://dx.doi.org/10.5114/ceji.2017.72285 |
_version_ | 1783349204333101056 |
---|---|
author | Sönmez, Mehmet G. Kozanhan, Betül Deniz, Çigˇdem D. Gögˇer, Yunus E. Kilinç, Muzaffer T. Neşeliogˇlu, Salim Ere, Özcan |
author_facet | Sönmez, Mehmet G. Kozanhan, Betül Deniz, Çigˇdem D. Gögˇer, Yunus E. Kilinç, Muzaffer T. Neşeliogˇlu, Salim Ere, Özcan |
author_sort | Sönmez, Mehmet G. |
collection | PubMed |
description | AIM OF THE STUDY: We aim to examine the relation between thiol/disulphide homeostasis and transrectal ultrasound guided prostate biopsy (TRUS-Bx) results and evaluate whether it was effective on the distinction of benign and malign prostate disease. MATERIAL AND METHODS: The study included 29 men histopathologically diagnosed as prostate adenocancer (Pca) (group 1), 30 men having benign prostate hyperplasia (BPH) (group 2) and age match 30 healthy individuals in the control group (group 3). Thiol/disulphide homeostasis was measured using a novel automatic and spectrophotometric method. RESULTS: Among the three groups, a statistically significant difference was detected among native thiol, total thiol levels and disulphide/total thiol, disulphide/native thiol and native thiol/total thiol ratios which are thiol/disulphide homeostasis parameters apart from disulphide (p < 0.001, p < 0.001, p < 0.001, p < 0.001, p < 0.001 respectively). Additionally, no significant difference was detected in albumin and total protein levels among the groups (p = 0.223, p = 0.316 respectively). Serum native and total thiol levels were high and disulphide level was low in group 1 when compared to the group 2 (p = 0.003, p = 0.007, p = 0.265 respectively). In addition, serum native thiol, total thiol and disulphide levels were low in group 1 when compared to the group 3, but while low native and total thiol levels were significant, low disulphide levels were not found significant (p < 0.001, p < 0.001, p = 0.331, respectively). CONCLUSIONS: Thiol/disulphide homeostasis was found to be disturbed in Pca patients detected with TRUS-Bx. This is suggesting serum native thiol, total thiol level and ratios provides a novel biomarker for the role for oxidative stress in disease etiopathogenesis. |
format | Online Article Text |
id | pubmed-6102614 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Polish Society of Experimental and Clinical Immunology |
record_format | MEDLINE/PubMed |
spelling | pubmed-61026142018-08-22 Is oxidative stress measured by thiol/disulphide homeostasis status associated with prostate adenocarcinoma? Sönmez, Mehmet G. Kozanhan, Betül Deniz, Çigˇdem D. Gögˇer, Yunus E. Kilinç, Muzaffer T. Neşeliogˇlu, Salim Ere, Özcan Cent Eur J Immunol Clinical Immunology AIM OF THE STUDY: We aim to examine the relation between thiol/disulphide homeostasis and transrectal ultrasound guided prostate biopsy (TRUS-Bx) results and evaluate whether it was effective on the distinction of benign and malign prostate disease. MATERIAL AND METHODS: The study included 29 men histopathologically diagnosed as prostate adenocancer (Pca) (group 1), 30 men having benign prostate hyperplasia (BPH) (group 2) and age match 30 healthy individuals in the control group (group 3). Thiol/disulphide homeostasis was measured using a novel automatic and spectrophotometric method. RESULTS: Among the three groups, a statistically significant difference was detected among native thiol, total thiol levels and disulphide/total thiol, disulphide/native thiol and native thiol/total thiol ratios which are thiol/disulphide homeostasis parameters apart from disulphide (p < 0.001, p < 0.001, p < 0.001, p < 0.001, p < 0.001 respectively). Additionally, no significant difference was detected in albumin and total protein levels among the groups (p = 0.223, p = 0.316 respectively). Serum native and total thiol levels were high and disulphide level was low in group 1 when compared to the group 2 (p = 0.003, p = 0.007, p = 0.265 respectively). In addition, serum native thiol, total thiol and disulphide levels were low in group 1 when compared to the group 3, but while low native and total thiol levels were significant, low disulphide levels were not found significant (p < 0.001, p < 0.001, p = 0.331, respectively). CONCLUSIONS: Thiol/disulphide homeostasis was found to be disturbed in Pca patients detected with TRUS-Bx. This is suggesting serum native thiol, total thiol level and ratios provides a novel biomarker for the role for oxidative stress in disease etiopathogenesis. Polish Society of Experimental and Clinical Immunology 2018-06-30 2018 /pmc/articles/PMC6102614/ /pubmed/30135630 http://dx.doi.org/10.5114/ceji.2017.72285 Text en Copyright: © 2018 Polish Society of Experimental and Clinical Immunology http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Clinical Immunology Sönmez, Mehmet G. Kozanhan, Betül Deniz, Çigˇdem D. Gögˇer, Yunus E. Kilinç, Muzaffer T. Neşeliogˇlu, Salim Ere, Özcan Is oxidative stress measured by thiol/disulphide homeostasis status associated with prostate adenocarcinoma? |
title | Is oxidative stress measured by thiol/disulphide homeostasis status associated with prostate adenocarcinoma? |
title_full | Is oxidative stress measured by thiol/disulphide homeostasis status associated with prostate adenocarcinoma? |
title_fullStr | Is oxidative stress measured by thiol/disulphide homeostasis status associated with prostate adenocarcinoma? |
title_full_unstemmed | Is oxidative stress measured by thiol/disulphide homeostasis status associated with prostate adenocarcinoma? |
title_short | Is oxidative stress measured by thiol/disulphide homeostasis status associated with prostate adenocarcinoma? |
title_sort | is oxidative stress measured by thiol/disulphide homeostasis status associated with prostate adenocarcinoma? |
topic | Clinical Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102614/ https://www.ncbi.nlm.nih.gov/pubmed/30135630 http://dx.doi.org/10.5114/ceji.2017.72285 |
work_keys_str_mv | AT sonmezmehmetg isoxidativestressmeasuredbythioldisulphidehomeostasisstatusassociatedwithprostateadenocarcinoma AT kozanhanbetul isoxidativestressmeasuredbythioldisulphidehomeostasisstatusassociatedwithprostateadenocarcinoma AT denizcigˇdemd isoxidativestressmeasuredbythioldisulphidehomeostasisstatusassociatedwithprostateadenocarcinoma AT gogˇeryunuse isoxidativestressmeasuredbythioldisulphidehomeostasisstatusassociatedwithprostateadenocarcinoma AT kilincmuzaffert isoxidativestressmeasuredbythioldisulphidehomeostasisstatusassociatedwithprostateadenocarcinoma AT neseliogˇlusalim isoxidativestressmeasuredbythioldisulphidehomeostasisstatusassociatedwithprostateadenocarcinoma AT ereozcan isoxidativestressmeasuredbythioldisulphidehomeostasisstatusassociatedwithprostateadenocarcinoma |