Three New Highly Oxygenated Germacranolides from Carpesium Divaricatum and Their Cytotoxic Activity

Three new highly oxygenated (2–4), and two known (1 and 5) germacranolides, were isolated from the whole plant of Carpesium divaricatum. The planar structures and relative configurations of the new compounds were determined by detailed spectroscopic analysis. The absolute configuration of 1 was esta...

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Autores principales: Zhang, Tao, Si, Jin-Guang, Zhang, Qiu-Bo, Chen, Jia-Huan, Ding, Gang, Zhang, Hong-Wu, Jia, Hong-Mei, Zou, Zhong-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102670/
https://www.ncbi.nlm.nih.gov/pubmed/29751555
http://dx.doi.org/10.3390/molecules23051078
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author Zhang, Tao
Si, Jin-Guang
Zhang, Qiu-Bo
Chen, Jia-Huan
Ding, Gang
Zhang, Hong-Wu
Jia, Hong-Mei
Zou, Zhong-Mei
author_facet Zhang, Tao
Si, Jin-Guang
Zhang, Qiu-Bo
Chen, Jia-Huan
Ding, Gang
Zhang, Hong-Wu
Jia, Hong-Mei
Zou, Zhong-Mei
author_sort Zhang, Tao
collection PubMed
description Three new highly oxygenated (2–4), and two known (1 and 5) germacranolides, were isolated from the whole plant of Carpesium divaricatum. The planar structures and relative configurations of the new compounds were determined by detailed spectroscopic analysis. The absolute configuration of 1 was established using the circular dichroism (CD) method and X-ray diffraction, and the stereochemistry of the new compounds 2–4 were determined using similar CD spectra with 1. The new compound 2 and the known compound 5 exhibited potent cytotoxicity against hepatocellular cancer (Hep G2) and human cervical cancer (HeLa) cells, superior to those of the positive control cis-platin.
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spelling pubmed-61026702018-11-13 Three New Highly Oxygenated Germacranolides from Carpesium Divaricatum and Their Cytotoxic Activity Zhang, Tao Si, Jin-Guang Zhang, Qiu-Bo Chen, Jia-Huan Ding, Gang Zhang, Hong-Wu Jia, Hong-Mei Zou, Zhong-Mei Molecules Article Three new highly oxygenated (2–4), and two known (1 and 5) germacranolides, were isolated from the whole plant of Carpesium divaricatum. The planar structures and relative configurations of the new compounds were determined by detailed spectroscopic analysis. The absolute configuration of 1 was established using the circular dichroism (CD) method and X-ray diffraction, and the stereochemistry of the new compounds 2–4 were determined using similar CD spectra with 1. The new compound 2 and the known compound 5 exhibited potent cytotoxicity against hepatocellular cancer (Hep G2) and human cervical cancer (HeLa) cells, superior to those of the positive control cis-platin. MDPI 2018-05-03 /pmc/articles/PMC6102670/ /pubmed/29751555 http://dx.doi.org/10.3390/molecules23051078 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Tao
Si, Jin-Guang
Zhang, Qiu-Bo
Chen, Jia-Huan
Ding, Gang
Zhang, Hong-Wu
Jia, Hong-Mei
Zou, Zhong-Mei
Three New Highly Oxygenated Germacranolides from Carpesium Divaricatum and Their Cytotoxic Activity
title Three New Highly Oxygenated Germacranolides from Carpesium Divaricatum and Their Cytotoxic Activity
title_full Three New Highly Oxygenated Germacranolides from Carpesium Divaricatum and Their Cytotoxic Activity
title_fullStr Three New Highly Oxygenated Germacranolides from Carpesium Divaricatum and Their Cytotoxic Activity
title_full_unstemmed Three New Highly Oxygenated Germacranolides from Carpesium Divaricatum and Their Cytotoxic Activity
title_short Three New Highly Oxygenated Germacranolides from Carpesium Divaricatum and Their Cytotoxic Activity
title_sort three new highly oxygenated germacranolides from carpesium divaricatum and their cytotoxic activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102670/
https://www.ncbi.nlm.nih.gov/pubmed/29751555
http://dx.doi.org/10.3390/molecules23051078
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