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Antimicrobial and toxicological evaluation of ethanol leaf extract of Salacia lehmbachii
The leaves of Salacia lehmbachii are used ethnomedically across Africa for the treatment of different diseases its antimicrobial activity as well as toxicological profile were evaluated. Antimicrobial activity against clinical strains of Pseudomonas aeruginosa, Salmonella typhi, Staphylococus aureus...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Slovak Toxicology Society SETOX
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102673/ https://www.ncbi.nlm.nih.gov/pubmed/30147424 http://dx.doi.org/10.1515/intox-2017-0023 |
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author | Essien, Augustine Dick Akuodor, Godwin Christian Ajoku, Gloria Ahunna Megwas, Anthony Uchenna Anele, Donatus Onyebuchi Ezeunala, Mercy Nwakaego Okezie, Alozie Ogwuegbu |
author_facet | Essien, Augustine Dick Akuodor, Godwin Christian Ajoku, Gloria Ahunna Megwas, Anthony Uchenna Anele, Donatus Onyebuchi Ezeunala, Mercy Nwakaego Okezie, Alozie Ogwuegbu |
author_sort | Essien, Augustine Dick |
collection | PubMed |
description | The leaves of Salacia lehmbachii are used ethnomedically across Africa for the treatment of different diseases its antimicrobial activity as well as toxicological profile were evaluated. Antimicrobial activity against clinical strains of Pseudomonas aeruginosa, Salmonella typhi, Staphylococus aureus, Shigella species, Eschericha coli and Proteus mirabilis were compared with Gentamycin. Toxicological investigation was determined by administering 100 mg/kg, 200 mg/kg and 400 mg/kg of the ethanol leaf extract to male Wistar rats for 21 days with distilled water as control. Hematological and biochemical parameters as well as the vital organs were examined. The ethanol extract inhibited the growth of P. aeruginosa, S. typhi, S. aureus, Shigella species, E. coli and P. mirabilis to varying extents. The LD(50) in rats was greater than 5000 mg/kg. Toxicological evaluation of the extract did not produce any significant effect on hematological and biochemical parameters and vital organs in rats. S. lehmbachii ethanol leaf extract did not demonstrate antimicrobial activity against selected microorganisms. Neither did it show any non-toxic effect on the parameters investigated in rats. Thus the extract can be considered safe when administered orally. |
format | Online Article Text |
id | pubmed-6102673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Slovak Toxicology Society SETOX |
record_format | MEDLINE/PubMed |
spelling | pubmed-61026732018-08-24 Antimicrobial and toxicological evaluation of ethanol leaf extract of Salacia lehmbachii Essien, Augustine Dick Akuodor, Godwin Christian Ajoku, Gloria Ahunna Megwas, Anthony Uchenna Anele, Donatus Onyebuchi Ezeunala, Mercy Nwakaego Okezie, Alozie Ogwuegbu Interdiscip Toxicol Original Article The leaves of Salacia lehmbachii are used ethnomedically across Africa for the treatment of different diseases its antimicrobial activity as well as toxicological profile were evaluated. Antimicrobial activity against clinical strains of Pseudomonas aeruginosa, Salmonella typhi, Staphylococus aureus, Shigella species, Eschericha coli and Proteus mirabilis were compared with Gentamycin. Toxicological investigation was determined by administering 100 mg/kg, 200 mg/kg and 400 mg/kg of the ethanol leaf extract to male Wistar rats for 21 days with distilled water as control. Hematological and biochemical parameters as well as the vital organs were examined. The ethanol extract inhibited the growth of P. aeruginosa, S. typhi, S. aureus, Shigella species, E. coli and P. mirabilis to varying extents. The LD(50) in rats was greater than 5000 mg/kg. Toxicological evaluation of the extract did not produce any significant effect on hematological and biochemical parameters and vital organs in rats. S. lehmbachii ethanol leaf extract did not demonstrate antimicrobial activity against selected microorganisms. Neither did it show any non-toxic effect on the parameters investigated in rats. Thus the extract can be considered safe when administered orally. Slovak Toxicology Society SETOX 2017-12 2018-03-01 /pmc/articles/PMC6102673/ /pubmed/30147424 http://dx.doi.org/10.1515/intox-2017-0023 Text en Copyright © 2017 SETOX & Institute of Experimental Pharmacology and Toxicology, SASc. https://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. (CC BY-NC-ND 4.0) |
spellingShingle | Original Article Essien, Augustine Dick Akuodor, Godwin Christian Ajoku, Gloria Ahunna Megwas, Anthony Uchenna Anele, Donatus Onyebuchi Ezeunala, Mercy Nwakaego Okezie, Alozie Ogwuegbu Antimicrobial and toxicological evaluation of ethanol leaf extract of Salacia lehmbachii |
title | Antimicrobial and toxicological evaluation of ethanol leaf extract of Salacia lehmbachii |
title_full | Antimicrobial and toxicological evaluation of ethanol leaf extract of Salacia lehmbachii |
title_fullStr | Antimicrobial and toxicological evaluation of ethanol leaf extract of Salacia lehmbachii |
title_full_unstemmed | Antimicrobial and toxicological evaluation of ethanol leaf extract of Salacia lehmbachii |
title_short | Antimicrobial and toxicological evaluation of ethanol leaf extract of Salacia lehmbachii |
title_sort | antimicrobial and toxicological evaluation of ethanol leaf extract of salacia lehmbachii |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102673/ https://www.ncbi.nlm.nih.gov/pubmed/30147424 http://dx.doi.org/10.1515/intox-2017-0023 |
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