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Antimicrobial and toxicological evaluation of ethanol leaf extract of Salacia lehmbachii

The leaves of Salacia lehmbachii are used ethnomedically across Africa for the treatment of different diseases its antimicrobial activity as well as toxicological profile were evaluated. Antimicrobial activity against clinical strains of Pseudomonas aeruginosa, Salmonella typhi, Staphylococus aureus...

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Autores principales: Essien, Augustine Dick, Akuodor, Godwin Christian, Ajoku, Gloria Ahunna, Megwas, Anthony Uchenna, Anele, Donatus Onyebuchi, Ezeunala, Mercy Nwakaego, Okezie, Alozie Ogwuegbu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Slovak Toxicology Society SETOX 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102673/
https://www.ncbi.nlm.nih.gov/pubmed/30147424
http://dx.doi.org/10.1515/intox-2017-0023
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author Essien, Augustine Dick
Akuodor, Godwin Christian
Ajoku, Gloria Ahunna
Megwas, Anthony Uchenna
Anele, Donatus Onyebuchi
Ezeunala, Mercy Nwakaego
Okezie, Alozie Ogwuegbu
author_facet Essien, Augustine Dick
Akuodor, Godwin Christian
Ajoku, Gloria Ahunna
Megwas, Anthony Uchenna
Anele, Donatus Onyebuchi
Ezeunala, Mercy Nwakaego
Okezie, Alozie Ogwuegbu
author_sort Essien, Augustine Dick
collection PubMed
description The leaves of Salacia lehmbachii are used ethnomedically across Africa for the treatment of different diseases its antimicrobial activity as well as toxicological profile were evaluated. Antimicrobial activity against clinical strains of Pseudomonas aeruginosa, Salmonella typhi, Staphylococus aureus, Shigella species, Eschericha coli and Proteus mirabilis were compared with Gentamycin. Toxicological investigation was determined by administering 100 mg/kg, 200 mg/kg and 400 mg/kg of the ethanol leaf extract to male Wistar rats for 21 days with distilled water as control. Hematological and biochemical parameters as well as the vital organs were examined. The ethanol extract inhibited the growth of P. aeruginosa, S. typhi, S. aureus, Shigella species, E. coli and P. mirabilis to varying extents. The LD(50) in rats was greater than 5000 mg/kg. Toxicological evaluation of the extract did not produce any significant effect on hematological and biochemical parameters and vital organs in rats. S. lehmbachii ethanol leaf extract did not demonstrate antimicrobial activity against selected microorganisms. Neither did it show any non-toxic effect on the parameters investigated in rats. Thus the extract can be considered safe when administered orally.
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spelling pubmed-61026732018-08-24 Antimicrobial and toxicological evaluation of ethanol leaf extract of Salacia lehmbachii Essien, Augustine Dick Akuodor, Godwin Christian Ajoku, Gloria Ahunna Megwas, Anthony Uchenna Anele, Donatus Onyebuchi Ezeunala, Mercy Nwakaego Okezie, Alozie Ogwuegbu Interdiscip Toxicol Original Article The leaves of Salacia lehmbachii are used ethnomedically across Africa for the treatment of different diseases its antimicrobial activity as well as toxicological profile were evaluated. Antimicrobial activity against clinical strains of Pseudomonas aeruginosa, Salmonella typhi, Staphylococus aureus, Shigella species, Eschericha coli and Proteus mirabilis were compared with Gentamycin. Toxicological investigation was determined by administering 100 mg/kg, 200 mg/kg and 400 mg/kg of the ethanol leaf extract to male Wistar rats for 21 days with distilled water as control. Hematological and biochemical parameters as well as the vital organs were examined. The ethanol extract inhibited the growth of P. aeruginosa, S. typhi, S. aureus, Shigella species, E. coli and P. mirabilis to varying extents. The LD(50) in rats was greater than 5000 mg/kg. Toxicological evaluation of the extract did not produce any significant effect on hematological and biochemical parameters and vital organs in rats. S. lehmbachii ethanol leaf extract did not demonstrate antimicrobial activity against selected microorganisms. Neither did it show any non-toxic effect on the parameters investigated in rats. Thus the extract can be considered safe when administered orally. Slovak Toxicology Society SETOX 2017-12 2018-03-01 /pmc/articles/PMC6102673/ /pubmed/30147424 http://dx.doi.org/10.1515/intox-2017-0023 Text en Copyright © 2017 SETOX & Institute of Experimental Pharmacology and Toxicology, SASc. https://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. (CC BY-NC-ND 4.0)
spellingShingle Original Article
Essien, Augustine Dick
Akuodor, Godwin Christian
Ajoku, Gloria Ahunna
Megwas, Anthony Uchenna
Anele, Donatus Onyebuchi
Ezeunala, Mercy Nwakaego
Okezie, Alozie Ogwuegbu
Antimicrobial and toxicological evaluation of ethanol leaf extract of Salacia lehmbachii
title Antimicrobial and toxicological evaluation of ethanol leaf extract of Salacia lehmbachii
title_full Antimicrobial and toxicological evaluation of ethanol leaf extract of Salacia lehmbachii
title_fullStr Antimicrobial and toxicological evaluation of ethanol leaf extract of Salacia lehmbachii
title_full_unstemmed Antimicrobial and toxicological evaluation of ethanol leaf extract of Salacia lehmbachii
title_short Antimicrobial and toxicological evaluation of ethanol leaf extract of Salacia lehmbachii
title_sort antimicrobial and toxicological evaluation of ethanol leaf extract of salacia lehmbachii
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102673/
https://www.ncbi.nlm.nih.gov/pubmed/30147424
http://dx.doi.org/10.1515/intox-2017-0023
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