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Could a Common Mechanism of Protein Degradation Impairment Underlie Many Neurodegenerative Diseases?
At the cellular level, many neurodegenerative diseases (NDs), often considered proteinopathies, are characterized by the accumulation of misfolded and damaged proteins into large insoluble aggregates. Prominent species that accumulate early and play fundamental roles in disease pathogenesis are amyl...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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SAGE Publications
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102758/ https://www.ncbi.nlm.nih.gov/pubmed/30147359 http://dx.doi.org/10.1177/1179069518794675 |