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Effect of TP53 rs1042522 on the susceptibility of patients to oral squamous cell carcinoma and oral leukoplakia: a meta-analysis

BACKGROUND: There are different and inconsistent conclusions regarding the genetic relationship between the human tumor suppressor p53 (TP53) rs1042522 polymorphism and the risk of oral squamous cell carcinoma (OSCC) and oral leukoplakia (OL). Therefore, the aim of the study was to comprehensively r...

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Autores principales: Sun, Zhen, Gao, Wei, Cui, Jiang-Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102817/
https://www.ncbi.nlm.nih.gov/pubmed/30126398
http://dx.doi.org/10.1186/s12903-018-0603-6
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author Sun, Zhen
Gao, Wei
Cui, Jiang-Tao
author_facet Sun, Zhen
Gao, Wei
Cui, Jiang-Tao
author_sort Sun, Zhen
collection PubMed
description BACKGROUND: There are different and inconsistent conclusions regarding the genetic relationship between the human tumor suppressor p53 (TP53) rs1042522 polymorphism and the risk of oral squamous cell carcinoma (OSCC) and oral leukoplakia (OL). Therefore, the aim of the study was to comprehensively reassess this association through the performance of an updated meta-analysis. METHODS: After searching the available databases, we systematically screened and included the eligible case-control studies, which contain the full genotype frequency data of the TP53 rs1042522 polymorphism for both OSCC/OL patients and the negative control groups. P(A) (P-value of the association test) and ORs (odd ratios) with their corresponding 95% CIs (confidence intervals) were calculated to quantitatively evaluate the influence of TP53 rs1042522 on the susceptibility of patients to OSCC or OL. RESULTS: In total, twenty eligible case-control articles were finally enrolled. Compared with the controls, no increased or decreased risk of OSCC was observed in the cases for six genetic models including allele C vs. G (P(A) = 0.741), carrier C vs. G (P(A) = 0.853), homozygote CC vs. GG (P(A) = 0.085), heterozygote GC vs. GG (P(A) = 0.882), dominant GC + CC vs. GG (P(A) = 0.969), and recessive CC vs. GG + GC (P(A) = 0.980). Furthermore, no statistically significant difference between the cases and controls was detected in most subgroup meta-analyses (P(A) > 0.05). For the risk of OL, we did not observe the difference between the cases and controls for most genetic models in the overall meta-analysis and subsequent subgroup analysis (P(A) > 0.05). Begg’s test and Egger’s test excluded the large risk of publication bias within the included studies in the meta-analysis of OSCC. The sensitivity analysis indicated the above relatively stable results. CONCLUSIONS: Our updated meta-analysis (based on the current evidence) shows that TP53 rs1042522 may not confer susceptibility to OSCC. In addition, for the first time, we provided evidence regarding the negative association between TP53 rs1042522 and OL risk. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12903-018-0603-6) contains supplementary material, which is available to authorized users.
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spelling pubmed-61028172018-08-27 Effect of TP53 rs1042522 on the susceptibility of patients to oral squamous cell carcinoma and oral leukoplakia: a meta-analysis Sun, Zhen Gao, Wei Cui, Jiang-Tao BMC Oral Health Research Article BACKGROUND: There are different and inconsistent conclusions regarding the genetic relationship between the human tumor suppressor p53 (TP53) rs1042522 polymorphism and the risk of oral squamous cell carcinoma (OSCC) and oral leukoplakia (OL). Therefore, the aim of the study was to comprehensively reassess this association through the performance of an updated meta-analysis. METHODS: After searching the available databases, we systematically screened and included the eligible case-control studies, which contain the full genotype frequency data of the TP53 rs1042522 polymorphism for both OSCC/OL patients and the negative control groups. P(A) (P-value of the association test) and ORs (odd ratios) with their corresponding 95% CIs (confidence intervals) were calculated to quantitatively evaluate the influence of TP53 rs1042522 on the susceptibility of patients to OSCC or OL. RESULTS: In total, twenty eligible case-control articles were finally enrolled. Compared with the controls, no increased or decreased risk of OSCC was observed in the cases for six genetic models including allele C vs. G (P(A) = 0.741), carrier C vs. G (P(A) = 0.853), homozygote CC vs. GG (P(A) = 0.085), heterozygote GC vs. GG (P(A) = 0.882), dominant GC + CC vs. GG (P(A) = 0.969), and recessive CC vs. GG + GC (P(A) = 0.980). Furthermore, no statistically significant difference between the cases and controls was detected in most subgroup meta-analyses (P(A) > 0.05). For the risk of OL, we did not observe the difference between the cases and controls for most genetic models in the overall meta-analysis and subsequent subgroup analysis (P(A) > 0.05). Begg’s test and Egger’s test excluded the large risk of publication bias within the included studies in the meta-analysis of OSCC. The sensitivity analysis indicated the above relatively stable results. CONCLUSIONS: Our updated meta-analysis (based on the current evidence) shows that TP53 rs1042522 may not confer susceptibility to OSCC. In addition, for the first time, we provided evidence regarding the negative association between TP53 rs1042522 and OL risk. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12903-018-0603-6) contains supplementary material, which is available to authorized users. BioMed Central 2018-08-20 /pmc/articles/PMC6102817/ /pubmed/30126398 http://dx.doi.org/10.1186/s12903-018-0603-6 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Sun, Zhen
Gao, Wei
Cui, Jiang-Tao
Effect of TP53 rs1042522 on the susceptibility of patients to oral squamous cell carcinoma and oral leukoplakia: a meta-analysis
title Effect of TP53 rs1042522 on the susceptibility of patients to oral squamous cell carcinoma and oral leukoplakia: a meta-analysis
title_full Effect of TP53 rs1042522 on the susceptibility of patients to oral squamous cell carcinoma and oral leukoplakia: a meta-analysis
title_fullStr Effect of TP53 rs1042522 on the susceptibility of patients to oral squamous cell carcinoma and oral leukoplakia: a meta-analysis
title_full_unstemmed Effect of TP53 rs1042522 on the susceptibility of patients to oral squamous cell carcinoma and oral leukoplakia: a meta-analysis
title_short Effect of TP53 rs1042522 on the susceptibility of patients to oral squamous cell carcinoma and oral leukoplakia: a meta-analysis
title_sort effect of tp53 rs1042522 on the susceptibility of patients to oral squamous cell carcinoma and oral leukoplakia: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102817/
https://www.ncbi.nlm.nih.gov/pubmed/30126398
http://dx.doi.org/10.1186/s12903-018-0603-6
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