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Synergy Between Proline-Rich Antimicrobial Peptides and Small Molecule Antibiotics Against Selected Gram-Negative Pathogens in vitro and in vivo

As monotherapy, modified proline-rich antimicrobial peptides (PrAMPs) protect animals from experimental bacteremia in a dose-dependent manner. We evaluated the in vitro synergy of a modified PrAMP, A3-APO, a dimer, previously shown to inhibit the 70 kDa bacterial heat shock protein DnaK, with imipen...

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Detalles Bibliográficos
Autores principales:	Otvos Jr., Laszlo, Ostorhazi, Eszter, Szabo, Dora, Zumbrun, Steven D., Miller, Lynda L., Halasohoris, Stephanie A., Desai, Puvi D., Int Veldt, Sharon M., Kraus, Carl N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102830/ https://www.ncbi.nlm.nih.gov/pubmed/30155456 http://dx.doi.org/10.3389/fchem.2018.00309

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