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Promoter expression of HERV-K (HML-2) provirus-derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites

BACKGROUND: Increased transcription of the human endogenous retrovirus group HERV-K (HML-2) is often seen during disease. Although the mechanism of its tissue-specific activation is unclear, research shows that LTR CpG hypomethylation alone is not sufficient to induce its promoter activity and that...

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Detalles Bibliográficos
Autores principales:	Montesion, Meagan, Williams, Zachary H., Subramanian, Ravi P., Kuperwasser, Charlotte, Coffin, John M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102855/ https://www.ncbi.nlm.nih.gov/pubmed/30126415 http://dx.doi.org/10.1186/s12977-018-0441-2

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