A randomized placebo controlled clinical trial to evaluate the efficacy and safety of minocycline in patients with Angelman syndrome (A-MANECE study)

BACKGROUND: Minocycline is an old tetracycline antibiotic that has shown antiinflammatory and antiapoptotic properties in different neurological disease mouse models. Previous single arm study in humans demonstrated benefits in individuals with Angelman Syndrome (AS); however, its efficacy in patien...

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Detalles Bibliográficos
Autores principales: Ruiz-Antoran, Belén, Sancho-López, Aranzazu, Cazorla-Calleja, Rosario, López-Pájaro, Luis Fernando, Leiva, Ágata, Iglesias-Escalera, Gema, Marín-Serrano, Maria Esperanza, Rincón-Ortega, Marta, Lara-Herguedas, Julián, Rossignoli-Palomeque, Teresa, Valiente-Rodríguez, Sara, González-Marques, Javier, Román-Riechmann, Enriqueta, Avendaño-Solá, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102900/
https://www.ncbi.nlm.nih.gov/pubmed/30126448
http://dx.doi.org/10.1186/s13023-018-0891-6

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