PD 1 checkpoint inhibition in solid organ transplants: 2 sides of a coin – case report

BACKGROUND: The management of malignancy post kidney transplantation includes reduction in immunosuppression and referral to an oncologist management of their malignancy. Recent advances in oncology have resulted in the approval of several classes of drugs with immune-modulatory activity. However, a...

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Detalles Bibliográficos
Autores principales: Goldman, Jonathan W., Abdalla, Basmah, Mendenhall, Melody A., Sisk, Anthony, Hunt, Jaime, Danovitch, Gabriel M., Lum, Erik L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102916/
https://www.ncbi.nlm.nih.gov/pubmed/30126374
http://dx.doi.org/10.1186/s12882-018-1003-5
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author Goldman, Jonathan W.
Abdalla, Basmah
Mendenhall, Melody A.
Sisk, Anthony
Hunt, Jaime
Danovitch, Gabriel M.
Lum, Erik L.
author_facet Goldman, Jonathan W.
Abdalla, Basmah
Mendenhall, Melody A.
Sisk, Anthony
Hunt, Jaime
Danovitch, Gabriel M.
Lum, Erik L.
author_sort Goldman, Jonathan W.
collection PubMed
description BACKGROUND: The management of malignancy post kidney transplantation includes reduction in immunosuppression and referral to an oncologist management of their malignancy. Recent advances in oncology have resulted in the approval of several classes of drugs with immune-modulatory activity. However, activation of the immune system against malignant cells may precipitate allograft rejection in solid organ transplant recipients. CASE PRESENTATION: Herein we present a case of acute kidney allograft rejection in a 50 year old man following administration of the novel immune-modulatory agent nivolumab for the treatment of metastatic squamous cell carcinoma. CONCLUSION: The management of malignancy in solid organ transplant recipients requires a heightened awareness of the potential for allograft rejection in this new era of cancer therapeutics.
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spelling pubmed-61029162018-08-30 PD 1 checkpoint inhibition in solid organ transplants: 2 sides of a coin – case report Goldman, Jonathan W. Abdalla, Basmah Mendenhall, Melody A. Sisk, Anthony Hunt, Jaime Danovitch, Gabriel M. Lum, Erik L. BMC Nephrol Case Report BACKGROUND: The management of malignancy post kidney transplantation includes reduction in immunosuppression and referral to an oncologist management of their malignancy. Recent advances in oncology have resulted in the approval of several classes of drugs with immune-modulatory activity. However, activation of the immune system against malignant cells may precipitate allograft rejection in solid organ transplant recipients. CASE PRESENTATION: Herein we present a case of acute kidney allograft rejection in a 50 year old man following administration of the novel immune-modulatory agent nivolumab for the treatment of metastatic squamous cell carcinoma. CONCLUSION: The management of malignancy in solid organ transplant recipients requires a heightened awareness of the potential for allograft rejection in this new era of cancer therapeutics. BioMed Central 2018-08-20 /pmc/articles/PMC6102916/ /pubmed/30126374 http://dx.doi.org/10.1186/s12882-018-1003-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Goldman, Jonathan W.
Abdalla, Basmah
Mendenhall, Melody A.
Sisk, Anthony
Hunt, Jaime
Danovitch, Gabriel M.
Lum, Erik L.
PD 1 checkpoint inhibition in solid organ transplants: 2 sides of a coin – case report
title PD 1 checkpoint inhibition in solid organ transplants: 2 sides of a coin – case report
title_full PD 1 checkpoint inhibition in solid organ transplants: 2 sides of a coin – case report
title_fullStr PD 1 checkpoint inhibition in solid organ transplants: 2 sides of a coin – case report
title_full_unstemmed PD 1 checkpoint inhibition in solid organ transplants: 2 sides of a coin – case report
title_short PD 1 checkpoint inhibition in solid organ transplants: 2 sides of a coin – case report
title_sort pd 1 checkpoint inhibition in solid organ transplants: 2 sides of a coin – case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102916/
https://www.ncbi.nlm.nih.gov/pubmed/30126374
http://dx.doi.org/10.1186/s12882-018-1003-5
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