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PD 1 checkpoint inhibition in solid organ transplants: 2 sides of a coin – case report
BACKGROUND: The management of malignancy post kidney transplantation includes reduction in immunosuppression and referral to an oncologist management of their malignancy. Recent advances in oncology have resulted in the approval of several classes of drugs with immune-modulatory activity. However, a...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102916/ https://www.ncbi.nlm.nih.gov/pubmed/30126374 http://dx.doi.org/10.1186/s12882-018-1003-5 |
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author | Goldman, Jonathan W. Abdalla, Basmah Mendenhall, Melody A. Sisk, Anthony Hunt, Jaime Danovitch, Gabriel M. Lum, Erik L. |
author_facet | Goldman, Jonathan W. Abdalla, Basmah Mendenhall, Melody A. Sisk, Anthony Hunt, Jaime Danovitch, Gabriel M. Lum, Erik L. |
author_sort | Goldman, Jonathan W. |
collection | PubMed |
description | BACKGROUND: The management of malignancy post kidney transplantation includes reduction in immunosuppression and referral to an oncologist management of their malignancy. Recent advances in oncology have resulted in the approval of several classes of drugs with immune-modulatory activity. However, activation of the immune system against malignant cells may precipitate allograft rejection in solid organ transplant recipients. CASE PRESENTATION: Herein we present a case of acute kidney allograft rejection in a 50 year old man following administration of the novel immune-modulatory agent nivolumab for the treatment of metastatic squamous cell carcinoma. CONCLUSION: The management of malignancy in solid organ transplant recipients requires a heightened awareness of the potential for allograft rejection in this new era of cancer therapeutics. |
format | Online Article Text |
id | pubmed-6102916 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-61029162018-08-30 PD 1 checkpoint inhibition in solid organ transplants: 2 sides of a coin – case report Goldman, Jonathan W. Abdalla, Basmah Mendenhall, Melody A. Sisk, Anthony Hunt, Jaime Danovitch, Gabriel M. Lum, Erik L. BMC Nephrol Case Report BACKGROUND: The management of malignancy post kidney transplantation includes reduction in immunosuppression and referral to an oncologist management of their malignancy. Recent advances in oncology have resulted in the approval of several classes of drugs with immune-modulatory activity. However, activation of the immune system against malignant cells may precipitate allograft rejection in solid organ transplant recipients. CASE PRESENTATION: Herein we present a case of acute kidney allograft rejection in a 50 year old man following administration of the novel immune-modulatory agent nivolumab for the treatment of metastatic squamous cell carcinoma. CONCLUSION: The management of malignancy in solid organ transplant recipients requires a heightened awareness of the potential for allograft rejection in this new era of cancer therapeutics. BioMed Central 2018-08-20 /pmc/articles/PMC6102916/ /pubmed/30126374 http://dx.doi.org/10.1186/s12882-018-1003-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Goldman, Jonathan W. Abdalla, Basmah Mendenhall, Melody A. Sisk, Anthony Hunt, Jaime Danovitch, Gabriel M. Lum, Erik L. PD 1 checkpoint inhibition in solid organ transplants: 2 sides of a coin – case report |
title | PD 1 checkpoint inhibition in solid organ transplants: 2 sides of a coin – case report |
title_full | PD 1 checkpoint inhibition in solid organ transplants: 2 sides of a coin – case report |
title_fullStr | PD 1 checkpoint inhibition in solid organ transplants: 2 sides of a coin – case report |
title_full_unstemmed | PD 1 checkpoint inhibition in solid organ transplants: 2 sides of a coin – case report |
title_short | PD 1 checkpoint inhibition in solid organ transplants: 2 sides of a coin – case report |
title_sort | pd 1 checkpoint inhibition in solid organ transplants: 2 sides of a coin – case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102916/ https://www.ncbi.nlm.nih.gov/pubmed/30126374 http://dx.doi.org/10.1186/s12882-018-1003-5 |
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