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Is IL-1β Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris

The pathogenesis of degenerative disc disease is a complex and multifactorial process in which genetics, mechanical trauma, altered loading and nutrition present significant etiological factors. Infection of the intervertebral disc with the anaerobic bacterium Propionibacterium acnes is now also eme...

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Autores principales: Slaby, Ondrej, McDowell, Andrew, Brüggemann, Holger, Raz, Assaf, Demir-Deviren, Sibel, Freemont, Tony, Lambert, Peter, Capoor, Manu N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103242/
https://www.ncbi.nlm.nih.gov/pubmed/30155445
http://dx.doi.org/10.3389/fcimb.2018.00272
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author Slaby, Ondrej
McDowell, Andrew
Brüggemann, Holger
Raz, Assaf
Demir-Deviren, Sibel
Freemont, Tony
Lambert, Peter
Capoor, Manu N.
author_facet Slaby, Ondrej
McDowell, Andrew
Brüggemann, Holger
Raz, Assaf
Demir-Deviren, Sibel
Freemont, Tony
Lambert, Peter
Capoor, Manu N.
author_sort Slaby, Ondrej
collection PubMed
description The pathogenesis of degenerative disc disease is a complex and multifactorial process in which genetics, mechanical trauma, altered loading and nutrition present significant etiological factors. Infection of the intervertebral disc with the anaerobic bacterium Propionibacterium acnes is now also emerging as a potentially new etiological factor. This human commensal bacterium is well known for its long association with the inflammatory skin condition acne vulgaris. A key component of inflammatory responses to P. acnes in acne appears to be interleukin (IL)-1β. Similarly, in degenerative disc disease (DDD) there is compelling evidence for the fundamental roles of IL-1β in its pathology. We therefore propose that P. acnes involvement in DDD is biologically very plausible, and that IL-1β is the key inflammatory mechanism driving the host response to P. acnes infection. Since there is a solid theoretical basis for this phenomenon, we further propose that the relationship between P. acnes infection and DDD is causal.
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spelling pubmed-61032422018-08-28 Is IL-1β Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris Slaby, Ondrej McDowell, Andrew Brüggemann, Holger Raz, Assaf Demir-Deviren, Sibel Freemont, Tony Lambert, Peter Capoor, Manu N. Front Cell Infect Microbiol Cellular and Infection Microbiology The pathogenesis of degenerative disc disease is a complex and multifactorial process in which genetics, mechanical trauma, altered loading and nutrition present significant etiological factors. Infection of the intervertebral disc with the anaerobic bacterium Propionibacterium acnes is now also emerging as a potentially new etiological factor. This human commensal bacterium is well known for its long association with the inflammatory skin condition acne vulgaris. A key component of inflammatory responses to P. acnes in acne appears to be interleukin (IL)-1β. Similarly, in degenerative disc disease (DDD) there is compelling evidence for the fundamental roles of IL-1β in its pathology. We therefore propose that P. acnes involvement in DDD is biologically very plausible, and that IL-1β is the key inflammatory mechanism driving the host response to P. acnes infection. Since there is a solid theoretical basis for this phenomenon, we further propose that the relationship between P. acnes infection and DDD is causal. Frontiers Media S.A. 2018-08-14 /pmc/articles/PMC6103242/ /pubmed/30155445 http://dx.doi.org/10.3389/fcimb.2018.00272 Text en Copyright © 2018 Slaby, McDowell, Brüggemann, Raz, Demir-Deviren, Freemont, Lambert and Capoor. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Slaby, Ondrej
McDowell, Andrew
Brüggemann, Holger
Raz, Assaf
Demir-Deviren, Sibel
Freemont, Tony
Lambert, Peter
Capoor, Manu N.
Is IL-1β Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris
title Is IL-1β Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris
title_full Is IL-1β Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris
title_fullStr Is IL-1β Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris
title_full_unstemmed Is IL-1β Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris
title_short Is IL-1β Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris
title_sort is il-1β further evidence for the role of propionibacterium acnes in degenerative disc disease? lessons from the study of the inflammatory skin condition acne vulgaris
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103242/
https://www.ncbi.nlm.nih.gov/pubmed/30155445
http://dx.doi.org/10.3389/fcimb.2018.00272
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