Transcriptomic analyses of murine ventricular cardiomyocytes

Mice are used universally as model organisms for studying heart physiology, and a plethora of genetically modified mouse models exist to study cardiac disease. Transcriptomic data for whole-heart tissue are available, but not yet for isolated ventricular cardiomyocytes. Our lab therefore collected c...

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Autores principales: Chevalier, Morgan, Vermij, Sarah H., Wyler, Kurt, Gillet, Ludovic, Keller, Irene, Abriel, Hugues
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Data Descriptor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103258/
https://www.ncbi.nlm.nih.gov/pubmed/30129933
http://dx.doi.org/10.1038/sdata.2018.170
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author Chevalier, Morgan
Vermij, Sarah H.
Wyler, Kurt
Gillet, Ludovic
Keller, Irene
Abriel, Hugues
author_facet Chevalier, Morgan
Vermij, Sarah H.
Wyler, Kurt
Gillet, Ludovic
Keller, Irene
Abriel, Hugues
author_sort Chevalier, Morgan
collection PubMed
description Mice are used universally as model organisms for studying heart physiology, and a plethora of genetically modified mouse models exist to study cardiac disease. Transcriptomic data for whole-heart tissue are available, but not yet for isolated ventricular cardiomyocytes. Our lab therefore collected comprehensive RNA-seq data from wildtype murine ventricular cardiomyocytes as well as from knockout models of the ion channel regulators CASK, dystrophin, and SAP97. We also elucidate ion channel expression from wild-type cells to help forward the debate about which ion channels are expressed in cardiomyocytes. Researchers studying the heart, and especially cardiac arrhythmias, may benefit from these cardiomyocyte-specific transcriptomic data to assess expression of genes of interest.
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spelling pubmed-61032582018-08-24 Transcriptomic analyses of murine ventricular cardiomyocytes Chevalier, Morgan Vermij, Sarah H. Wyler, Kurt Gillet, Ludovic Keller, Irene Abriel, Hugues Sci Data Data Descriptor Mice are used universally as model organisms for studying heart physiology, and a plethora of genetically modified mouse models exist to study cardiac disease. Transcriptomic data for whole-heart tissue are available, but not yet for isolated ventricular cardiomyocytes. Our lab therefore collected comprehensive RNA-seq data from wildtype murine ventricular cardiomyocytes as well as from knockout models of the ion channel regulators CASK, dystrophin, and SAP97. We also elucidate ion channel expression from wild-type cells to help forward the debate about which ion channels are expressed in cardiomyocytes. Researchers studying the heart, and especially cardiac arrhythmias, may benefit from these cardiomyocyte-specific transcriptomic data to assess expression of genes of interest. Nature Publishing Group 2018-08-21 /pmc/articles/PMC6103258/ /pubmed/30129933 http://dx.doi.org/10.1038/sdata.2018.170 Text en Copyright © 2018, The Author(s) http://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ The Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the metadata files made available in this article.
spellingShingle Data Descriptor
Chevalier, Morgan
Vermij, Sarah H.
Wyler, Kurt
Gillet, Ludovic
Keller, Irene
Abriel, Hugues
Transcriptomic analyses of murine ventricular cardiomyocytes
title Transcriptomic analyses of murine ventricular cardiomyocytes
title_full Transcriptomic analyses of murine ventricular cardiomyocytes
title_fullStr Transcriptomic analyses of murine ventricular cardiomyocytes
title_full_unstemmed Transcriptomic analyses of murine ventricular cardiomyocytes
title_short Transcriptomic analyses of murine ventricular cardiomyocytes
title_sort transcriptomic analyses of murine ventricular cardiomyocytes
topic Data Descriptor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103258/
https://www.ncbi.nlm.nih.gov/pubmed/30129933
http://dx.doi.org/10.1038/sdata.2018.170
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