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Chronic Gastritis Due to Helicobacter Pylori Associated with Increased Serum Levels of CA54/61: A Report of Three Cases
Case series Patient: Female, 44 • Male, 73 • Male, 54 Final Diagnosis: Chronic gastritis Symptoms: Abnormal value of a tumor marker Medication: — Clinical Procedure: Eradication therapy of Helicobacter pylori Specialty: Gastroenterology and Hepatology OBJECTIVE: Unusual clinical course BACKGROUND: T...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103271/ https://www.ncbi.nlm.nih.gov/pubmed/30104559 http://dx.doi.org/10.12659/AJCR.909299 |
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author | Yagura, Toshihiro Egawa, Shinichi Okano, Akihiro Mizukoshi, Kenta |
author_facet | Yagura, Toshihiro Egawa, Shinichi Okano, Akihiro Mizukoshi, Kenta |
author_sort | Yagura, Toshihiro |
collection | PubMed |
description | Case series Patient: Female, 44 • Male, 73 • Male, 54 Final Diagnosis: Chronic gastritis Symptoms: Abnormal value of a tumor marker Medication: — Clinical Procedure: Eradication therapy of Helicobacter pylori Specialty: Gastroenterology and Hepatology OBJECTIVE: Unusual clinical course BACKGROUND: The bacterial pathogen Helicobacter pylori (H. pylori) can cause chronic gastritis. CA54/61 is a serum tumor marker that has been shown to be positive in the several types of human malignancy. However, the association of between chronic gastritis due to H. pylori and elevated serum levels of CA54/61 has not been previously reported. This report is of three cases of increased serum levels of CA54/61 associated with H. pylori chronic gastritis. CASE REPORTS: Case 1 was a 44-year-old Japanese woman with a serum CA54/61 level of 138 U/ml (normal level: 12 U/ml). Following treatment and eradication of H. pylori the serum CA54/61 level decreased to 14 U/ml. Case 2 was a 73-year-old Japanese man with a serum level of less than 2 U/ml before completion of successful eradication therapy of H. pylori with a small peak of 30 U/ml after therapy. Case 3 was a 54-year-old Japanese man who maintained a serum CA54/61 level of approximately 20 U/ml before and until 603 days after eradication therapy. None of the three patients had malignancy, which is usually suggested by this serum marker. CONCLUSIONS: These three case reports suggest the possibility of an association between chronic gastritis involving H. pylori infection and an elevated serum level of CA54/61. It is possible that the inflammatory gastric mucosal cells supply CA54/61 to the bloodstream. However, further studies are required to confirm the association between serum levels of CA54/61 and H. pylori chronic gastritis and the underlying mechanisms of this association. |
format | Online Article Text |
id | pubmed-6103271 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61032712018-08-23 Chronic Gastritis Due to Helicobacter Pylori Associated with Increased Serum Levels of CA54/61: A Report of Three Cases Yagura, Toshihiro Egawa, Shinichi Okano, Akihiro Mizukoshi, Kenta Am J Case Rep Articles Case series Patient: Female, 44 • Male, 73 • Male, 54 Final Diagnosis: Chronic gastritis Symptoms: Abnormal value of a tumor marker Medication: — Clinical Procedure: Eradication therapy of Helicobacter pylori Specialty: Gastroenterology and Hepatology OBJECTIVE: Unusual clinical course BACKGROUND: The bacterial pathogen Helicobacter pylori (H. pylori) can cause chronic gastritis. CA54/61 is a serum tumor marker that has been shown to be positive in the several types of human malignancy. However, the association of between chronic gastritis due to H. pylori and elevated serum levels of CA54/61 has not been previously reported. This report is of three cases of increased serum levels of CA54/61 associated with H. pylori chronic gastritis. CASE REPORTS: Case 1 was a 44-year-old Japanese woman with a serum CA54/61 level of 138 U/ml (normal level: 12 U/ml). Following treatment and eradication of H. pylori the serum CA54/61 level decreased to 14 U/ml. Case 2 was a 73-year-old Japanese man with a serum level of less than 2 U/ml before completion of successful eradication therapy of H. pylori with a small peak of 30 U/ml after therapy. Case 3 was a 54-year-old Japanese man who maintained a serum CA54/61 level of approximately 20 U/ml before and until 603 days after eradication therapy. None of the three patients had malignancy, which is usually suggested by this serum marker. CONCLUSIONS: These three case reports suggest the possibility of an association between chronic gastritis involving H. pylori infection and an elevated serum level of CA54/61. It is possible that the inflammatory gastric mucosal cells supply CA54/61 to the bloodstream. However, further studies are required to confirm the association between serum levels of CA54/61 and H. pylori chronic gastritis and the underlying mechanisms of this association. International Scientific Literature, Inc. 2018-08-14 /pmc/articles/PMC6103271/ /pubmed/30104559 http://dx.doi.org/10.12659/AJCR.909299 Text en © Am J Case Rep, 2018 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Articles Yagura, Toshihiro Egawa, Shinichi Okano, Akihiro Mizukoshi, Kenta Chronic Gastritis Due to Helicobacter Pylori Associated with Increased Serum Levels of CA54/61: A Report of Three Cases |
title | Chronic Gastritis Due to Helicobacter Pylori Associated with Increased Serum Levels of CA54/61: A Report of Three Cases |
title_full | Chronic Gastritis Due to Helicobacter Pylori Associated with Increased Serum Levels of CA54/61: A Report of Three Cases |
title_fullStr | Chronic Gastritis Due to Helicobacter Pylori Associated with Increased Serum Levels of CA54/61: A Report of Three Cases |
title_full_unstemmed | Chronic Gastritis Due to Helicobacter Pylori Associated with Increased Serum Levels of CA54/61: A Report of Three Cases |
title_short | Chronic Gastritis Due to Helicobacter Pylori Associated with Increased Serum Levels of CA54/61: A Report of Three Cases |
title_sort | chronic gastritis due to helicobacter pylori associated with increased serum levels of ca54/61: a report of three cases |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103271/ https://www.ncbi.nlm.nih.gov/pubmed/30104559 http://dx.doi.org/10.12659/AJCR.909299 |
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