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Transcription factor target site search and gene regulation in a background of unspecific binding sites

Response time and transcription level are vital parameters of gene regulation. They depend on how fast transcription factors (TFs) find and how efficient they occupy their specific target sites. It is well known that target site search is accelerated by TF binding to and sliding along unspecific DNA...

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Detalles Bibliográficos
Autores principales: Hettich, J., Gebhardt, J.C.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103292/
https://www.ncbi.nlm.nih.gov/pubmed/29870697
http://dx.doi.org/10.1016/j.jtbi.2018.05.037