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Dual-energy computed tomography using a gantry-based preclinical cone-beam microcomputed tomography scanner
Dual-energy microcomputed tomography (DECT) can provide quantitative information about specific materials of interest, facilitating automated segmentation, and visualization of complex three-dimensional tissues. It is possible to implement DECT on currently available preclinical gantry-based cone-be...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society of Photo-Optical Instrumentation Engineers
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103383/ https://www.ncbi.nlm.nih.gov/pubmed/30155511 http://dx.doi.org/10.1117/1.JMI.5.3.033503 |
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author | Tse, Justin J. Dunmore-Buyze, Joy Drangova, Maria Holdsworth, David W. |
author_facet | Tse, Justin J. Dunmore-Buyze, Joy Drangova, Maria Holdsworth, David W. |
author_sort | Tse, Justin J. |
collection | PubMed |
description | Dual-energy microcomputed tomography (DECT) can provide quantitative information about specific materials of interest, facilitating automated segmentation, and visualization of complex three-dimensional tissues. It is possible to implement DECT on currently available preclinical gantry-based cone-beam micro-CT scanners; however, optimal decomposition image quality requires customized spectral shaping (through added filtration), optimized acquisition protocols, and elimination of misregistration artifacts. We present a method for the fabrication of customized x-ray filters—in both shape and elemental composition—needed for spectral shaping. Fiducial markers, integrated within the sample holder, were used to ensure accurate co-registration between sequential low- and high-energy image volumes. The entire acquisition process was automated through the use of a motorized filter-exchange mechanism. We describe the design, implementation, and evaluation of a DECT system on a gantry-based-preclinical cone-beam micro-CT scanner. |
format | Online Article Text |
id | pubmed-6103383 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Society of Photo-Optical Instrumentation Engineers |
record_format | MEDLINE/PubMed |
spelling | pubmed-61033832019-08-21 Dual-energy computed tomography using a gantry-based preclinical cone-beam microcomputed tomography scanner Tse, Justin J. Dunmore-Buyze, Joy Drangova, Maria Holdsworth, David W. J Med Imaging (Bellingham) Physics of Medical Imaging Dual-energy microcomputed tomography (DECT) can provide quantitative information about specific materials of interest, facilitating automated segmentation, and visualization of complex three-dimensional tissues. It is possible to implement DECT on currently available preclinical gantry-based cone-beam micro-CT scanners; however, optimal decomposition image quality requires customized spectral shaping (through added filtration), optimized acquisition protocols, and elimination of misregistration artifacts. We present a method for the fabrication of customized x-ray filters—in both shape and elemental composition—needed for spectral shaping. Fiducial markers, integrated within the sample holder, were used to ensure accurate co-registration between sequential low- and high-energy image volumes. The entire acquisition process was automated through the use of a motorized filter-exchange mechanism. We describe the design, implementation, and evaluation of a DECT system on a gantry-based-preclinical cone-beam micro-CT scanner. Society of Photo-Optical Instrumentation Engineers 2018-08-21 2018-07 /pmc/articles/PMC6103383/ /pubmed/30155511 http://dx.doi.org/10.1117/1.JMI.5.3.033503 Text en © The Authors. https://creativecommons.org/licenses/by/3.0/ Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. |
spellingShingle | Physics of Medical Imaging Tse, Justin J. Dunmore-Buyze, Joy Drangova, Maria Holdsworth, David W. Dual-energy computed tomography using a gantry-based preclinical cone-beam microcomputed tomography scanner |
title | Dual-energy computed tomography using a gantry-based preclinical cone-beam microcomputed tomography scanner |
title_full | Dual-energy computed tomography using a gantry-based preclinical cone-beam microcomputed tomography scanner |
title_fullStr | Dual-energy computed tomography using a gantry-based preclinical cone-beam microcomputed tomography scanner |
title_full_unstemmed | Dual-energy computed tomography using a gantry-based preclinical cone-beam microcomputed tomography scanner |
title_short | Dual-energy computed tomography using a gantry-based preclinical cone-beam microcomputed tomography scanner |
title_sort | dual-energy computed tomography using a gantry-based preclinical cone-beam microcomputed tomography scanner |
topic | Physics of Medical Imaging |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103383/ https://www.ncbi.nlm.nih.gov/pubmed/30155511 http://dx.doi.org/10.1117/1.JMI.5.3.033503 |
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