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Diagnostic performance of contrast-enhanced ultrasound and enhanced magnetic resonance for breast nodules

In the current study, we sought to evaluate the diagnostic efficacies of conventional ultrasound (US), contrast-enhanced US (CEUS), combined US and CEUS and magnetic resonance imaging (MRI) in detecting focal solid breast lesions. Totally 117 patients with 120 BI-RADS category 4A-5 breast lesions we...

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Autores principales: Li, Cuiying, Gong, Haiyan, Ling, Lijun, Du, Liwen, Su, Tong, Wang, Shui, Wang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Department of Journal of Biomedical Research 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103473/
https://www.ncbi.nlm.nih.gov/pubmed/29921747
http://dx.doi.org/10.7555/JBR.32.20180015
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author Li, Cuiying
Gong, Haiyan
Ling, Lijun
Du, Liwen
Su, Tong
Wang, Shui
Wang, Jie
author_facet Li, Cuiying
Gong, Haiyan
Ling, Lijun
Du, Liwen
Su, Tong
Wang, Shui
Wang, Jie
author_sort Li, Cuiying
collection PubMed
description In the current study, we sought to evaluate the diagnostic efficacies of conventional ultrasound (US), contrast-enhanced US (CEUS), combined US and CEUS and magnetic resonance imaging (MRI) in detecting focal solid breast lesions. Totally 117 patients with 120 BI-RADS category 4A-5 breast lesions were evaluated by conventional US and CEUS, and MRI, respectively. SonoVue was used as contrast agent in CEUS and injected as an intravenous bolus; nodule scan was performed 4 minutes after bolus injection. A specific sonographic quantification software was used to obtain color-coded maps of perfusion parameters for the investigated lesion, namely the time-intensity curve. The pattern of contrast enhancement and related indexes regarding the time-intensity curve were used to describe the lesions, comparatively with pathological results. Histopathologic examination revealed 46 benign and 74 malignant lesions. Sensitivity, specificity, and accuracy of US in detecting malignant breast lesions were 90.14%, 95.92%, and 92.52%, respectively. Meanwhile, CE-MRI showed sensitivity, specificity, and accuracy of 88.73%, 95.92%, and 91.67%, respectively. The area under the ROC curve for combined US and CEUS in discriminating benign from malignant breast lesions was 0.936, while that of MRI was 0.923, with no significant difference between them, as well as among groups. The time-intensity curve of malignant hypervascular fibroadenoma and papillary lesions mostly showed a fast-in/fast-out pattern, with no good correlation between them (kappa<0.20). In conclusion, the combined use of conventional US and CEUS displays good agreement with MRI in differentiating benign from malignant breast lesions.
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spelling pubmed-61034732018-08-23 Diagnostic performance of contrast-enhanced ultrasound and enhanced magnetic resonance for breast nodules Li, Cuiying Gong, Haiyan Ling, Lijun Du, Liwen Su, Tong Wang, Shui Wang, Jie J Biomed Res Original Article In the current study, we sought to evaluate the diagnostic efficacies of conventional ultrasound (US), contrast-enhanced US (CEUS), combined US and CEUS and magnetic resonance imaging (MRI) in detecting focal solid breast lesions. Totally 117 patients with 120 BI-RADS category 4A-5 breast lesions were evaluated by conventional US and CEUS, and MRI, respectively. SonoVue was used as contrast agent in CEUS and injected as an intravenous bolus; nodule scan was performed 4 minutes after bolus injection. A specific sonographic quantification software was used to obtain color-coded maps of perfusion parameters for the investigated lesion, namely the time-intensity curve. The pattern of contrast enhancement and related indexes regarding the time-intensity curve were used to describe the lesions, comparatively with pathological results. Histopathologic examination revealed 46 benign and 74 malignant lesions. Sensitivity, specificity, and accuracy of US in detecting malignant breast lesions were 90.14%, 95.92%, and 92.52%, respectively. Meanwhile, CE-MRI showed sensitivity, specificity, and accuracy of 88.73%, 95.92%, and 91.67%, respectively. The area under the ROC curve for combined US and CEUS in discriminating benign from malignant breast lesions was 0.936, while that of MRI was 0.923, with no significant difference between them, as well as among groups. The time-intensity curve of malignant hypervascular fibroadenoma and papillary lesions mostly showed a fast-in/fast-out pattern, with no good correlation between them (kappa<0.20). In conclusion, the combined use of conventional US and CEUS displays good agreement with MRI in differentiating benign from malignant breast lesions. Editorial Department of Journal of Biomedical Research 2018-06-26 2018-05-06 /pmc/articles/PMC6103473/ /pubmed/29921747 http://dx.doi.org/10.7555/JBR.32.20180015 Text en © 2018 by the Journal of Biomedical Research. All rights reserved /creativecommons.org/licenses/by/4.0/ This is an open access article under the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited.
spellingShingle Original Article
Li, Cuiying
Gong, Haiyan
Ling, Lijun
Du, Liwen
Su, Tong
Wang, Shui
Wang, Jie
Diagnostic performance of contrast-enhanced ultrasound and enhanced magnetic resonance for breast nodules
title Diagnostic performance of contrast-enhanced ultrasound and enhanced magnetic resonance for breast nodules
title_full Diagnostic performance of contrast-enhanced ultrasound and enhanced magnetic resonance for breast nodules
title_fullStr Diagnostic performance of contrast-enhanced ultrasound and enhanced magnetic resonance for breast nodules
title_full_unstemmed Diagnostic performance of contrast-enhanced ultrasound and enhanced magnetic resonance for breast nodules
title_short Diagnostic performance of contrast-enhanced ultrasound and enhanced magnetic resonance for breast nodules
title_sort diagnostic performance of contrast-enhanced ultrasound and enhanced magnetic resonance for breast nodules
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103473/
https://www.ncbi.nlm.nih.gov/pubmed/29921747
http://dx.doi.org/10.7555/JBR.32.20180015
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