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Epithelial autophagy controls chronic colitis by reducing TNF-induced apoptosis

Genome-wide association studies (GWAS) linking polymorphisms in ATG16L1 with susceptibility to inflammatory bowel disease (IBD) have prompted mucosal immunologists to investigate the functional roles of macroautophagy/autophagy in different cell types in the gut. Here we present a recent study that...

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Detalles Bibliográficos
Autores principales: Pott, Johanna, Maloy, Kevin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103553/
https://www.ncbi.nlm.nih.gov/pubmed/29799774
http://dx.doi.org/10.1080/15548627.2018.1450021
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author Pott, Johanna
Maloy, Kevin J.
author_facet Pott, Johanna
Maloy, Kevin J.
author_sort Pott, Johanna
collection PubMed
description Genome-wide association studies (GWAS) linking polymorphisms in ATG16L1 with susceptibility to inflammatory bowel disease (IBD) have prompted mucosal immunologists to investigate the functional roles of macroautophagy/autophagy in different cell types in the gut. Here we present a recent study that addressed 2 key questions: in which cell type is autophagy deficiency most detrimental during chronic colitis and what is the functional role of autophagy in those cells? We report that autophagy in intestinal epithelial cells (IECs) acts to limit intestinal inflammation by protecting them from TNF-induced apoptosis and we discuss the potential implications for IBD treatment.
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spelling pubmed-61035532018-08-29 Epithelial autophagy controls chronic colitis by reducing TNF-induced apoptosis Pott, Johanna Maloy, Kevin J. Autophagy Autophagic Punctum Genome-wide association studies (GWAS) linking polymorphisms in ATG16L1 with susceptibility to inflammatory bowel disease (IBD) have prompted mucosal immunologists to investigate the functional roles of macroautophagy/autophagy in different cell types in the gut. Here we present a recent study that addressed 2 key questions: in which cell type is autophagy deficiency most detrimental during chronic colitis and what is the functional role of autophagy in those cells? We report that autophagy in intestinal epithelial cells (IECs) acts to limit intestinal inflammation by protecting them from TNF-induced apoptosis and we discuss the potential implications for IBD treatment. Taylor & Francis 2018-05-25 /pmc/articles/PMC6103553/ /pubmed/29799774 http://dx.doi.org/10.1080/15548627.2018.1450021 Text en © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Autophagic Punctum
Pott, Johanna
Maloy, Kevin J.
Epithelial autophagy controls chronic colitis by reducing TNF-induced apoptosis
title Epithelial autophagy controls chronic colitis by reducing TNF-induced apoptosis
title_full Epithelial autophagy controls chronic colitis by reducing TNF-induced apoptosis
title_fullStr Epithelial autophagy controls chronic colitis by reducing TNF-induced apoptosis
title_full_unstemmed Epithelial autophagy controls chronic colitis by reducing TNF-induced apoptosis
title_short Epithelial autophagy controls chronic colitis by reducing TNF-induced apoptosis
title_sort epithelial autophagy controls chronic colitis by reducing tnf-induced apoptosis
topic Autophagic Punctum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103553/
https://www.ncbi.nlm.nih.gov/pubmed/29799774
http://dx.doi.org/10.1080/15548627.2018.1450021
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AT maloykevinj epithelialautophagycontrolschroniccolitisbyreducingtnfinducedapoptosis