Cargando…
Epithelial autophagy controls chronic colitis by reducing TNF-induced apoptosis
Genome-wide association studies (GWAS) linking polymorphisms in ATG16L1 with susceptibility to inflammatory bowel disease (IBD) have prompted mucosal immunologists to investigate the functional roles of macroautophagy/autophagy in different cell types in the gut. Here we present a recent study that...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103553/ https://www.ncbi.nlm.nih.gov/pubmed/29799774 http://dx.doi.org/10.1080/15548627.2018.1450021 |
_version_ | 1783349359221407744 |
---|---|
author | Pott, Johanna Maloy, Kevin J. |
author_facet | Pott, Johanna Maloy, Kevin J. |
author_sort | Pott, Johanna |
collection | PubMed |
description | Genome-wide association studies (GWAS) linking polymorphisms in ATG16L1 with susceptibility to inflammatory bowel disease (IBD) have prompted mucosal immunologists to investigate the functional roles of macroautophagy/autophagy in different cell types in the gut. Here we present a recent study that addressed 2 key questions: in which cell type is autophagy deficiency most detrimental during chronic colitis and what is the functional role of autophagy in those cells? We report that autophagy in intestinal epithelial cells (IECs) acts to limit intestinal inflammation by protecting them from TNF-induced apoptosis and we discuss the potential implications for IBD treatment. |
format | Online Article Text |
id | pubmed-6103553 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-61035532018-08-29 Epithelial autophagy controls chronic colitis by reducing TNF-induced apoptosis Pott, Johanna Maloy, Kevin J. Autophagy Autophagic Punctum Genome-wide association studies (GWAS) linking polymorphisms in ATG16L1 with susceptibility to inflammatory bowel disease (IBD) have prompted mucosal immunologists to investigate the functional roles of macroautophagy/autophagy in different cell types in the gut. Here we present a recent study that addressed 2 key questions: in which cell type is autophagy deficiency most detrimental during chronic colitis and what is the functional role of autophagy in those cells? We report that autophagy in intestinal epithelial cells (IECs) acts to limit intestinal inflammation by protecting them from TNF-induced apoptosis and we discuss the potential implications for IBD treatment. Taylor & Francis 2018-05-25 /pmc/articles/PMC6103553/ /pubmed/29799774 http://dx.doi.org/10.1080/15548627.2018.1450021 Text en © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Autophagic Punctum Pott, Johanna Maloy, Kevin J. Epithelial autophagy controls chronic colitis by reducing TNF-induced apoptosis |
title | Epithelial autophagy controls chronic colitis by reducing TNF-induced apoptosis |
title_full | Epithelial autophagy controls chronic colitis by reducing TNF-induced apoptosis |
title_fullStr | Epithelial autophagy controls chronic colitis by reducing TNF-induced apoptosis |
title_full_unstemmed | Epithelial autophagy controls chronic colitis by reducing TNF-induced apoptosis |
title_short | Epithelial autophagy controls chronic colitis by reducing TNF-induced apoptosis |
title_sort | epithelial autophagy controls chronic colitis by reducing tnf-induced apoptosis |
topic | Autophagic Punctum |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103553/ https://www.ncbi.nlm.nih.gov/pubmed/29799774 http://dx.doi.org/10.1080/15548627.2018.1450021 |
work_keys_str_mv | AT pottjohanna epithelialautophagycontrolschroniccolitisbyreducingtnfinducedapoptosis AT maloykevinj epithelialautophagycontrolschroniccolitisbyreducingtnfinducedapoptosis |