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Potential Prophylactic Effect of Berberine against Rat Colon Carcinoma Induce by 1,2-Dimethyl Hydrazine

INTRODUCTION: Colon Cancer remains one of the major worldwide causes of cancer related morbidity and mortality in both genders. Berberine (BBR), a major component of alkaloids that possess a variety of pharmacological properties. OBJECTIVE: This study shows the ameliorating roles of berberine on 1,2...

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Autores principales: Ghareeb, Ahmed E, Moawed, Fatma S M, Ghareeb, Doaa A, Kandil, Eman I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103593/
https://www.ncbi.nlm.nih.gov/pubmed/29938466
http://dx.doi.org/10.22034/APJCP.2018.19.6.1685
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author Ghareeb, Ahmed E
Moawed, Fatma S M
Ghareeb, Doaa A
Kandil, Eman I
author_facet Ghareeb, Ahmed E
Moawed, Fatma S M
Ghareeb, Doaa A
Kandil, Eman I
author_sort Ghareeb, Ahmed E
collection PubMed
description INTRODUCTION: Colon Cancer remains one of the major worldwide causes of cancer related morbidity and mortality in both genders. Berberine (BBR), a major component of alkaloids that possess a variety of pharmacological properties. OBJECTIVE: This study shows the ameliorating roles of berberine on 1,2 Di methyl hydrazine (DMH) induced colon cancer in male Swiss albino rats. METHODS: The rats were segregated into four groups: group 1, control rats; group 2, rats were orally received berberine (75 mg/kg b.wt./day) daily for ten weeks; group 3, rats were subcutaneously injected with DMH (20 mg/kg b.wt) once a week for 8 weeks, group 4, rats were treated firstly with berberine for two weeks before DMH intoxication and concurrently with DMH over 8 weeks. RESULT: DMH injection decreased the antioxidants levels (GSH and SOD) and increased inflammatory markers (MPO, MAPK and COX-2). Moreover, it downregulated apoptotic markers (Caspase-3 and P53) expression that confirmed by colon cell proliferation. The prophylactic effect of berberine was noticed as its pre-and co-administration increased antioxidants status and apoptotic markers expression that associated with inflammatory markers down-regulation with absence of proliferated colon cells. CONCLUSION: Therefore, the overall findings proved that the anti-proliferative effect of berberine return to its antioxidants and anti-inflammatory properties that activated the programmed cell death process.
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spelling pubmed-61035932018-08-28 Potential Prophylactic Effect of Berberine against Rat Colon Carcinoma Induce by 1,2-Dimethyl Hydrazine Ghareeb, Ahmed E Moawed, Fatma S M Ghareeb, Doaa A Kandil, Eman I Asian Pac J Cancer Prev Research Article INTRODUCTION: Colon Cancer remains one of the major worldwide causes of cancer related morbidity and mortality in both genders. Berberine (BBR), a major component of alkaloids that possess a variety of pharmacological properties. OBJECTIVE: This study shows the ameliorating roles of berberine on 1,2 Di methyl hydrazine (DMH) induced colon cancer in male Swiss albino rats. METHODS: The rats were segregated into four groups: group 1, control rats; group 2, rats were orally received berberine (75 mg/kg b.wt./day) daily for ten weeks; group 3, rats were subcutaneously injected with DMH (20 mg/kg b.wt) once a week for 8 weeks, group 4, rats were treated firstly with berberine for two weeks before DMH intoxication and concurrently with DMH over 8 weeks. RESULT: DMH injection decreased the antioxidants levels (GSH and SOD) and increased inflammatory markers (MPO, MAPK and COX-2). Moreover, it downregulated apoptotic markers (Caspase-3 and P53) expression that confirmed by colon cell proliferation. The prophylactic effect of berberine was noticed as its pre-and co-administration increased antioxidants status and apoptotic markers expression that associated with inflammatory markers down-regulation with absence of proliferated colon cells. CONCLUSION: Therefore, the overall findings proved that the anti-proliferative effect of berberine return to its antioxidants and anti-inflammatory properties that activated the programmed cell death process. West Asia Organization for Cancer Prevention 2018 /pmc/articles/PMC6103593/ /pubmed/29938466 http://dx.doi.org/10.22034/APJCP.2018.19.6.1685 Text en Copyright: © Asian Pacific Journal of Cancer Prevention http://creativecommons.org/licenses/BY-SA/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Research Article
Ghareeb, Ahmed E
Moawed, Fatma S M
Ghareeb, Doaa A
Kandil, Eman I
Potential Prophylactic Effect of Berberine against Rat Colon Carcinoma Induce by 1,2-Dimethyl Hydrazine
title Potential Prophylactic Effect of Berberine against Rat Colon Carcinoma Induce by 1,2-Dimethyl Hydrazine
title_full Potential Prophylactic Effect of Berberine against Rat Colon Carcinoma Induce by 1,2-Dimethyl Hydrazine
title_fullStr Potential Prophylactic Effect of Berberine against Rat Colon Carcinoma Induce by 1,2-Dimethyl Hydrazine
title_full_unstemmed Potential Prophylactic Effect of Berberine against Rat Colon Carcinoma Induce by 1,2-Dimethyl Hydrazine
title_short Potential Prophylactic Effect of Berberine against Rat Colon Carcinoma Induce by 1,2-Dimethyl Hydrazine
title_sort potential prophylactic effect of berberine against rat colon carcinoma induce by 1,2-dimethyl hydrazine
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103593/
https://www.ncbi.nlm.nih.gov/pubmed/29938466
http://dx.doi.org/10.22034/APJCP.2018.19.6.1685
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