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Effect of intravitreal ranibizumab on serous retinal detachment in branch retinal vein occlusion

PURPOSE: The aim of this study was to evaluate the effect of initial intravitreal ranibizumab injection on visual acuity (VA) and central macular thickness (CMT) for the treatment of macular edema (ME) with and without serous retinal detachment (SRD) secondary to branch retinal vein occlusion (BRVO)...

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Autores principales: Dogan, Emine, Sever, Ozkan, Köklü Çakır, Burcin, Celik, Erkan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103606/
https://www.ncbi.nlm.nih.gov/pubmed/30154642
http://dx.doi.org/10.2147/OPTH.S162019
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author Dogan, Emine
Sever, Ozkan
Köklü Çakır, Burcin
Celik, Erkan
author_facet Dogan, Emine
Sever, Ozkan
Köklü Çakır, Burcin
Celik, Erkan
author_sort Dogan, Emine
collection PubMed
description PURPOSE: The aim of this study was to evaluate the effect of initial intravitreal ranibizumab injection on visual acuity (VA) and central macular thickness (CMT) for the treatment of macular edema (ME) with and without serous retinal detachment (SRD) secondary to branch retinal vein occlusion (BRVO). MATERIALS AND METHODS: Fifty-two BRVO eyes, treated with intravitreal ranibizumab injection for ME with and without SRD, were retrospectively reviewed. Patients were divided into two groups according to spectral domain optical coherence tomography (SD-OCT). The efficacy of intravitreal ranibizumab injection at first month was assessed by analyzing the change in best-corrected VA and reduction in CMT with SD-OCT. RESULTS: There were 21 patients with SRD and 31 patients with only CME (no-SRD). CMT was significantly greater in the SRD group than in the CME group (451±62.2 µm vs 383.5±37.2 µm, respectively, P<0.05). After initial intravitreal ranibizumab injection, mean VA improved from 0.87±0.26 logarithm of the minimum angle of resolution (LogMAR) to 0.54±0.27 LogMAR (P<0.01) and CMT decreased from 451±62.2 µm to 379.3±58.6 µm (P<0.001) in the SRD group. In the no-SRD group, mean VA improved from 0.69±0.25 LogMAR to 0.44±0.25 LogMAR (P<0.001) and the CMT decreased from 383.5±37.2 µm to 337.7±39.4 µm (P<0.001) at the first month visit. Eyes with SRD revealed better anatomic results and greater reduction of CMT after intravitreal ranibizumab injection (P<0.01). CONCLUSION: VA and CMT can be improved by intravitreal ranibizumab injection in BRVO patients with and without SRD. However, more marked improvement in macular morphology was achieved in patients with SRD than those without SRD.
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spelling pubmed-61036062018-08-28 Effect of intravitreal ranibizumab on serous retinal detachment in branch retinal vein occlusion Dogan, Emine Sever, Ozkan Köklü Çakır, Burcin Celik, Erkan Clin Ophthalmol Original Research PURPOSE: The aim of this study was to evaluate the effect of initial intravitreal ranibizumab injection on visual acuity (VA) and central macular thickness (CMT) for the treatment of macular edema (ME) with and without serous retinal detachment (SRD) secondary to branch retinal vein occlusion (BRVO). MATERIALS AND METHODS: Fifty-two BRVO eyes, treated with intravitreal ranibizumab injection for ME with and without SRD, were retrospectively reviewed. Patients were divided into two groups according to spectral domain optical coherence tomography (SD-OCT). The efficacy of intravitreal ranibizumab injection at first month was assessed by analyzing the change in best-corrected VA and reduction in CMT with SD-OCT. RESULTS: There were 21 patients with SRD and 31 patients with only CME (no-SRD). CMT was significantly greater in the SRD group than in the CME group (451±62.2 µm vs 383.5±37.2 µm, respectively, P<0.05). After initial intravitreal ranibizumab injection, mean VA improved from 0.87±0.26 logarithm of the minimum angle of resolution (LogMAR) to 0.54±0.27 LogMAR (P<0.01) and CMT decreased from 451±62.2 µm to 379.3±58.6 µm (P<0.001) in the SRD group. In the no-SRD group, mean VA improved from 0.69±0.25 LogMAR to 0.44±0.25 LogMAR (P<0.001) and the CMT decreased from 383.5±37.2 µm to 337.7±39.4 µm (P<0.001) at the first month visit. Eyes with SRD revealed better anatomic results and greater reduction of CMT after intravitreal ranibizumab injection (P<0.01). CONCLUSION: VA and CMT can be improved by intravitreal ranibizumab injection in BRVO patients with and without SRD. However, more marked improvement in macular morphology was achieved in patients with SRD than those without SRD. Dove Medical Press 2018-08-17 /pmc/articles/PMC6103606/ /pubmed/30154642 http://dx.doi.org/10.2147/OPTH.S162019 Text en © 2018 Dogan et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Dogan, Emine
Sever, Ozkan
Köklü Çakır, Burcin
Celik, Erkan
Effect of intravitreal ranibizumab on serous retinal detachment in branch retinal vein occlusion
title Effect of intravitreal ranibizumab on serous retinal detachment in branch retinal vein occlusion
title_full Effect of intravitreal ranibizumab on serous retinal detachment in branch retinal vein occlusion
title_fullStr Effect of intravitreal ranibizumab on serous retinal detachment in branch retinal vein occlusion
title_full_unstemmed Effect of intravitreal ranibizumab on serous retinal detachment in branch retinal vein occlusion
title_short Effect of intravitreal ranibizumab on serous retinal detachment in branch retinal vein occlusion
title_sort effect of intravitreal ranibizumab on serous retinal detachment in branch retinal vein occlusion
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103606/
https://www.ncbi.nlm.nih.gov/pubmed/30154642
http://dx.doi.org/10.2147/OPTH.S162019
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