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Mechanisms of the effectiveness of poly(ε-caprolactone) lipid-core nanocapsules loaded with methotrexate on glioblastoma multiforme treatment

PURPOSE: The low penetration of drugs across the blood–brain barrier (BBB) compromises the delivery of chemotherapeutic agents to the brain parenchyma and contributes to the poor prognosis of glioblastoma multiforme (GBM). We investigated the efficacy of methotrexate-loaded lipid-core nanocapsules (...

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Detalles Bibliográficos
Autores principales:	Pereira, Natalia Rubio Claret, Loiola, Rodrigo Azevedo, Rodrigues, Stephen Fernandes, de Oliveira, Catiuscia P, Büttenbender, Sabrina L, Guterres, Silvia S, Pohlmann, Adriana R, Farsky, Sandra H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103652/ https://www.ncbi.nlm.nih.gov/pubmed/30154652 http://dx.doi.org/10.2147/IJN.S168400

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